Novel and facile criterion to assess the accuracy of WSS estimation by 4D flow MRI

Abstract

Four-dimensional flow magnetic resonance imaging (4D flow MRI) is a versatile tool to obtain hemodynamic information and anatomic information simultaneously. The wall shear stress (WSS), a force exerted on a vessel wall in parallel, is one of the hemodynamic parameters available with 4D flow MRI and is thought to play an important role in clinical applications such as assessing the development of atherosclerosis. Nevertheless, the accuracy of WSS obtained with 4D flow MRI is rarely evaluated or reported in literature, especially in the in vivo studies. We propose a novel and facile criterion called Reynolds resolution to assess the accuracy of WSS estimation in 4D flow MRI studies. Reynolds resolution consists of a spatial resolution, encoding velocity, kinematic viscosity of a working fluid, and signal-to-noise ratio, which are readily accessible information in 4D flow MRI measurements. We explored the relationship between Reynolds resolution and the WSS error. To include diverse and extensive cases, we measured three circular tubing flows with a diameter of 40, 8, and 2 mm. The 40mm tubing flow was measured by 3 Tesla (T) human MR scanner with a knee coil and spatial resolution of 0.5 mm. The 8 and 2mm tubing flows were both measured by 4.7 T MR scanner, but the scans were performed with a conventional birdcage coil (8 mm tubing) and a custom-made solenoid coil (2 mm tubing), respectively. The spatial resolution was varied from 0.2, 0.4 or 0.8mm for the 8 mm tubing flow, but was fixed at 0.090mm for 2mm tubing flow. In addition, the near-wall velocity gradient, required to be determined prior to the WSS, was calculated using two methods; these included assuming a linear velocity profile or quadratic velocity profile near wall. The accuracy of WSS obtained using each method and tubing flow was evaluated against the theoretical WSS value. As a result, we found that Reynolds resolution is in logarithmic relation to the WSS error. (C) 2019 Elsevier B.V. All rights reserved.