Spatial Functional Characteristics of East Asian Patients With Occult Macular Dystrophy (Miyake Disease); EAOMD Report No. 2
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Lizhu | - |
dc.contributor.author | Joo, Kwangsic | - |
dc.contributor.author | Tsunoda, Kazushige | - |
dc.contributor.author | Kondo, Mineo | - |
dc.contributor.author | Fujinami-Yokokawa, Yu | - |
dc.contributor.author | Arno, Gavin | - |
dc.contributor.author | Pontikos, Nikolas | - |
dc.contributor.author | Liu, Xiao | - |
dc.contributor.author | Nakamura, Natsuko | - |
dc.contributor.author | Kurihara, Toshihide | - |
dc.contributor.author | Tsubota, Kazuo | - |
dc.contributor.author | Iwata, Takeshi | - |
dc.contributor.author | Li, Hui | - |
dc.contributor.author | Zou, Xuan | - |
dc.contributor.author | Wu, Shijing | - |
dc.contributor.author | Sun, Zixi | - |
dc.contributor.author | Ahn, Seong Joon | - |
dc.contributor.author | Kim, Min Seok | - |
dc.contributor.author | Mun, Yong Seok | - |
dc.contributor.author | Park, Kyu Hyung | - |
dc.contributor.author | Robson, Anthony G. | - |
dc.contributor.author | Miyake, Yozo | - |
dc.contributor.author | Woo, Se Joon | - |
dc.contributor.author | Sui, Ruifang | - |
dc.contributor.author | Fujinami, Kaoru | - |
dc.date.accessioned | 2022-07-07T01:40:33Z | - |
dc.date.available | 2022-07-07T01:40:33Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142475 | - |
dc.description.abstract | Purpose: To describe the functional phenotypic features of East Asian patients with RP1L1-associated occult macular dystrophy (ie, Miyake disease). Design: An international multicenter retrospective cohort study. Methods: Twenty-eight participants (53 eyes) with Miyake disease were enrolled at 3 centers (in Japan, China, and South Korea). Ophthalmologic examinations including spectral-domain optical coherence tomography (SDOCT) and multifocal electroretinogram (mfERG) were performed. Patients were classified into 3 functional groups based on mfERG: Group 1, paracentral dysfunction with relatively preserved central/peripheral function; Group 2, homogeneous central dysfunction with preserved peripheral function; and Group 3, widespread dysfunction over the recorded area. Three functional phenotypes were compared in clinical parameters and SDOCT morphologic classification (severe phenotype, blurred/flat ellipsoid zone and absence of the interdigitation zone; mild phenotype, preserved ellipsoid zone). Results: There were 8 eyes in Group 1, 40 eyes in Group 2, and 5 eyes in Group 3. The patients in Group 1 showed significantly later onset (P = .005) and shorter disease duration (P = .002), compared with those in Group 2. All 8 eyes in Group 1 showed the mild morphologic phenotype, while 43 of 45 eyes in Groups 2 and 3 presented the severe phenotype, which identified a significant association between the functional grouping and the morphologic classification (P < .001). Conclusions: A spectrum of functional phenotypes of Miyake disease was first documented with identification of 3 functional subtypes. Patients with paracentral dysfunction had the mildest phenotype, and those with homogeneous central or widespread dysfunction showed overlapping clinical findings with severe photoreceptor changes, suggesting various extents of visual impairment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Spatial Functional Characteristics of East Asian Patients With Occult Macular Dystrophy (Miyake Disease); EAOMD Report No. 2 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Seong Joon | - |
dc.identifier.doi | 10.1016/j.ajo.2020.07.025 | - |
dc.identifier.scopusid | 2-s2.0-85093067229 | - |
dc.identifier.wosid | 000599616500019 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF OPHTHALMOLOGY, v.221, pp.169 - 180 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF OPHTHALMOLOGY | - |
dc.citation.title | AMERICAN JOURNAL OF OPHTHALMOLOGY | - |
dc.citation.volume | 221 | - |
dc.citation.startPage | 169 | - |
dc.citation.endPage | 180 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | MULTIFOCAL ELECTRORETINOGRAPHY | - |
dc.subject.keywordPlus | FUNDUS AUTOFLUORESCENCE | - |
dc.subject.keywordPlus | RETINITIS-PIGMENTOSA | - |
dc.subject.keywordPlus | STARGARDT DISEASE | - |
dc.subject.keywordPlus | RP1L1 VARIANTS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | MFERG | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0002939420303822?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.