Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Jun, Sun-Young | - |
dc.contributor.author | Chung, Joon-Yong | - |
dc.contributor.author | Yoon, Nara | - |
dc.contributor.author | Jung, Eun Sun | - |
dc.contributor.author | Oh, Young-Ha | - |
dc.contributor.author | Hong, Seung-Mo | - |
dc.date.accessioned | 2022-07-07T02:38:40Z | - |
dc.date.available | 2022-07-07T02:38:40Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142599 | - |
dc.description.abstract | The clinicopathologic and prognostic significances of tumor budding (TB) and poorly-differentiated clusters (PDC) have not been investigated in small intestinal adenocarcinomas (SIACs). In 236 surgically-resected SIACs, we counted TB (single cells or clusters ≤4 tumor cells) and PDC (clusters ≥5 tumor cells) at the peritumoral-invasive front (p) and in the intratumoral area (i) independently to classify as grade-1 (≤4), grade-2 (5–9), or grade-3 (≥10). Consequently, grades-2 and -3 were considered high-grade. High-pTB, -iTB, -pPDC, and -iPDC were observed in 174 (73.7%), 129 (54.7%), 118 (50.0%), and 85 (36.0%) cases, respectively. High-TB/PDCs were more frequently observed in tumors with high-grade, higher T- and N-categories and stage grouping, and perineural or lymphovascular invasion. Patients with high-TB/PDC had a shorter survival than those with low-TB/PDC. In a multivariate analysis, high-pTB, nonintestinal type, high N-category, retroperitoneal seeding, and microsatellite-stable were worse independent-prognostic predictors. Subgroup analysis demonstrated that patients with high-pTB showed worse survival (median: 42.5 months) than those with low-pTB (133.7 months; p = 0.007) in the lower stage (stages I–II) group. High-TB/PDC, both in peritumoral and intratumoral localizations, were associated with aggressive behaviors in SIACs. High-pTB can be used as an adverse prognostic indicator in SIAC patients, especially when patients are in early disease stages. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Young-Ha | - |
dc.identifier.doi | 10.3390/cancers12082199 | - |
dc.identifier.scopusid | 2-s2.0-85089550632 | - |
dc.identifier.wosid | 000578984700001 | - |
dc.identifier.bibliographicCitation | CANCERS, v.12, no.8, pp.1 - 16 | - |
dc.relation.isPartOf | CANCERS | - |
dc.citation.title | CANCERS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 16 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | SMALL-BOWEL ADENOCARCINOMA | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | BRAF MUTATIONS | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | LYMPH-NODE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | STAGE | - |
dc.subject.keywordAuthor | small intestine | - |
dc.subject.keywordAuthor | adenocarcinoma | - |
dc.subject.keywordAuthor | tumor budding | - |
dc.subject.keywordAuthor | poorly differentiated clusters | - |
dc.subject.keywordAuthor | prognosis | - |
dc.identifier.url | https://www.mdpi.com/2072-6694/12/8/2199 | - |
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