GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang-Heon | - |
dc.contributor.author | Kim, Sang-Hoon | - |
dc.contributor.author | Yoon, Ho Joo | - |
dc.contributor.author | Shin, Dong Ho | - |
dc.contributor.author | Park, Sung Soo | - |
dc.contributor.author | Kim, Youn-Seup | - |
dc.contributor.author | Park, Jae-Seuk | - |
dc.contributor.author | Jee, Young Koo | - |
dc.date.accessioned | 2022-07-07T03:49:23Z | - |
dc.date.available | 2022-07-07T03:49:23Z | - |
dc.date.created | 2022-06-17 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 1472-9792 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142785 | - |
dc.description.abstract | Adverse reactions induced by antituberculosis drugs (ATD) often result in serious morbidities, impeding scheduled treatment and cure. In the development of ATD-induced adverse reactions, glutathione S-transferase has been suggested to play a protective role as an intracellular scavenger by conjugating toxic reactive metabolites of ATD. This study examined the association of null mutations in GST enzyme genes (GSTT1 and GSTM1) with the development of ATD-induced hepatitis and cutaneous reactions. We compared the frequencies of GSTT1 and GSTM1 null mutations in 57 patients with hepatitis, 94 patients with cutaneous adverse reactions, and 190 ATD-tolerant controls. The frequency of null mutations in GSTT1 and GSTM1 in patients with ATD-induced hepatitis was not significantly different from that of controls (59.6% vs. 54.2% and 45.6% vs. 54.7%, respectively). Additionally, no significant difference was observed in the frequency of either null mutation in patients with ATD-induced cutaneous reactions, including maculopapular eruption, compared with controls (58.5% vs. 54.1% for GSTT1 and 59.6% vs. 54.6% for GSTM1). These findings indicate that GSTT1 and GSTM1 null mutations are not associated with the development of ATD-induced hepatitis or cutaneous reactions in this Korean population, and suggest that glutathione S-transferase enzymes do not play important roles in the pathogenesis of these conditions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CHURCHILL LIVINGSTONE | - |
dc.title | GSTT1 and GSTM1 null mutations and adverse reactions induced by antituberculosis drugs in Koreans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Sang-Heon | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Joo | - |
dc.identifier.doi | 10.1016/j.tube.2009.12.001 | - |
dc.identifier.scopusid | 2-s2.0-75149127243 | - |
dc.identifier.wosid | 000274081100007 | - |
dc.identifier.bibliographicCitation | TUBERCULOSIS, v.90, no.1, pp.39 - 43 | - |
dc.relation.isPartOf | TUBERCULOSIS | - |
dc.citation.title | TUBERCULOSIS | - |
dc.citation.volume | 90 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 43 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | S-TRANSFERASE M1 | - |
dc.subject.keywordPlus | INDUCED LIVER-INJURY | - |
dc.subject.keywordPlus | INDUCED HEPATOTOXICITY | - |
dc.subject.keywordPlus | GENETIC POLYMORPHISMS | - |
dc.subject.keywordPlus | INDUCED HEPATITIS | - |
dc.subject.keywordPlus | N-ACETYLTRANSFERASE-2 GENE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | TUBERCULOSIS | - |
dc.subject.keywordPlus | HYPERSENSITIVITY | - |
dc.subject.keywordAuthor | Antituberculosis drugs | - |
dc.subject.keywordAuthor | Adverse drug reactions | - |
dc.subject.keywordAuthor | Glutathione S-transferase enzyme | - |
dc.subject.keywordAuthor | Hepatotoxicity | - |
dc.subject.keywordAuthor | Adverse cutaneous reactions | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1472979209001206?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.