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N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates
- Issue Date
- Nov-2015
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- copper; N-arylation; indoles; copper-mediated synthesis; heterocyclic amines; metal-catalyzed
- Citation
- SYNTHESIS-STUTTGART, v.47, no.21, pp.3301 - 3308
- Indexed
- SCIE
SCOPUS
- Journal Title
- SYNTHESIS-STUTTGART
- Volume
- 47
- Number
- 21
- Start Page
- 3301
- End Page
- 3308
- ISSN
- 0039-7881
- Abstract
- Indole-carboxylates are N-arylated with 2-bromopyridines using stoichiometric copper(II) oxide/potassium carbonate to give various N-(2-pyridyl)-substituted indole-2-carboxylates and with bromobenzenes using stoichiometric copper(I) iodide/N,N'-dimethylethylenediamine to give various N-(substituted phenyl)-substituted indole-2-carboxylates. These results expand the scope of metal-catalyzed N-arylation using heterocyclic amines with steric bulk and weak nucleophilicity.
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Related Researcher
- Shin, Seung hoon
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF CHEMISTRY)