Systemic Delivery of Helical Polypeptide Induces Tumor-Specific Apoptosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kasala, Dayananda | - |
dc.contributor.author | Lee, DaeYong | - |
dc.contributor.author | Lee, Soo-Hwan | - |
dc.contributor.author | Na, Youjin | - |
dc.contributor.author | Noh, Ilkoo | - |
dc.contributor.author | Ha, JongHoon | - |
dc.contributor.author | Yoo, Jisang | - |
dc.contributor.author | Bang, Hyun Bae | - |
dc.contributor.author | Park, Jong Hyun | - |
dc.contributor.author | Jeong, Ki Jun | - |
dc.contributor.author | Kim, Yeu-Chun | - |
dc.contributor.author | Yun, Chae-Ok | - |
dc.date.accessioned | 2021-08-02T11:54:17Z | - |
dc.date.available | 2021-08-02T11:54:17Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/14301 | - |
dc.description.abstract | A cationic helical peptide (CHP) has been intensively used as a gene or drug delivery carrier, and as antibiotics for therapeutic purposes in biomedical fields. CHPs are insufficient as delivery systems because they have a short chain length giving rise to a low helical propensity. In an effort to resolve these inherent limitations, artificial cationic helical polypeptides (ACHP) have been recently devised by further modifications of the side chains in functional group-bearing polypeptides. ACHP possess higher cell-penetrating property than conventional cell-penetrating peptides. However, these ACHP do not possess specificity toward diseases and penetrates into cells indiscriminately like their predecessors. To address these limitations, we have added pH-sensitive anion-donating groups to a helical polypeptide enable the peptide to selectively penetrate into tumors through pH-dependent formational change of peptide following exposure to acidic tumor microenvironment. The mitochondriadestabilizing helical polypeptide undergoing pH-dependent conformational transitions led to efficient targeting of tumors and disruption of mitochondrial membranes, thus leading to tumorspecific induction of apoptosis. This work presents a promising peptide therapeutic system for cancer therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Systemic Delivery of Helical Polypeptide Induces Tumor-Specific Apoptosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Chae-Ok | - |
dc.identifier.wosid | 000464381002162 | - |
dc.identifier.bibliographicCitation | MOLECULAR THERAPY, v.27, no.4, pp.235 - 235 | - |
dc.relation.isPartOf | MOLECULAR THERAPY | - |
dc.citation.title | MOLECULAR THERAPY | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 235 | - |
dc.citation.endPage | 235 | - |
dc.type.rims | ART | - |
dc.type.docType | Meeting Abstract | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.identifier.url | https://www.cell.com/molecular-therapy/archive#decade=loi_decade_201 | - |
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