Piceatannol inhibits effector T cell functions by suppressing TcR signaling
DC Field | Value | Language |
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dc.contributor.author | Kim, Do-Hyun | - |
dc.contributor.author | Lee, Yong-Gab | - |
dc.contributor.author | Park, Hong-Jai | - |
dc.contributor.author | Lee, Jung-Ah | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Hwang, Jae-Kwan | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2022-07-07T05:43:06Z | - |
dc.date.available | 2022-07-07T05:43:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-04 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143556 | - |
dc.description.abstract | Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of piceatannol has been extensively studied, its role in the adaptive immune response has received less attention. Here we investigated the role of piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFN gamma, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naive CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38. Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Piceatannol inhibits effector T cell functions by suppressing TcR signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.1016/j.intimp.2015.01.030 | - |
dc.identifier.scopusid | 2-s2.0-84923545309 | - |
dc.identifier.wosid | 000352669600007 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.25, no.2, pp.285 - 292 | - |
dc.relation.isPartOf | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 285 | - |
dc.citation.endPage | 292 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE KINASE | - |
dc.subject.keywordPlus | PROSTATE-CANCER CELLS | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | MEDIATED ACTIVATION | - |
dc.subject.keywordPlus | ANTIGEN RECEPTOR | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | U937 CELLS | - |
dc.subject.keywordPlus | RESVERATROL | - |
dc.subject.keywordPlus | ZAP-70 | - |
dc.subject.keywordAuthor | Piceatannol | - |
dc.subject.keywordAuthor | T cells | - |
dc.subject.keywordAuthor | TcR signaling | - |
dc.subject.keywordAuthor | T cell proliferation | - |
dc.subject.keywordAuthor | T cell differentiation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1567576915000466?via%3Dihub | - |
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