TGF beta 1 Protects Cells from gamma-IR by Enhancing the Activity of the NHEJ Repair Pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Mi-Ra | - |
dc.contributor.author | Lee, Jeeyong | - |
dc.contributor.author | An, You Sun | - |
dc.contributor.author | Jin, Yeung Bae | - |
dc.contributor.author | Park, In-Chul | - |
dc.contributor.author | Chung, Eunkyung | - |
dc.contributor.author | Shin, Incheol | - |
dc.contributor.author | Barcellos-Hoff, Mary Helen | - |
dc.contributor.author | Yi, Jae Youn | - |
dc.date.accessioned | 2022-07-07T07:39:37Z | - |
dc.date.available | 2022-07-07T07:39:37Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143854 | - |
dc.description.abstract | Several groups have reported that TGF beta 1 regulates cellular responses to gamma-irradiation; however, the exact mechanism has not been fully elucidated. In the current study, the role of TGF beta 1 in cellular responses to gamma-irradiation was investigated in detail. The data indicate that TGF beta 1 pretreatment decreased the aftermath of ionizing radiation (IR)-induced DNA damage in a SMAD-dependent manner. To determine the underlying mechanism for these effects, the extent of IR-induced DNA repair activity in the presence or absence of TGF beta 1 was examined. Studies reveal that TGF beta 1 upregulated DNA ligase IV (Lig4), augmented IR-induced nuclear retention of the DNA ligase, and enhanced nonhomologous end-joining (NHEJ) repair activity. In addition, knockdown of Lig4 reduced the TGF beta 1-induced protection against IR. Overall, these data indicate that TGF beta 1 facilitates the NHEJ repair process upon gamma-irradiation and thereby enhances long-term survival. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | TGF beta 1 Protects Cells from gamma-IR by Enhancing the Activity of the NHEJ Repair Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Incheol | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-14-0098-T | - |
dc.identifier.scopusid | 2-s2.0-84923879744 | - |
dc.identifier.wosid | 000351219800011 | - |
dc.identifier.bibliographicCitation | MOLECULAR CANCER RESEARCH, v.13, no.2, pp.319 - 329 | - |
dc.relation.isPartOf | MOLECULAR CANCER RESEARCH | - |
dc.citation.title | MOLECULAR CANCER RESEARCH | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 319 | - |
dc.citation.endPage | 329 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DOUBLE-STRAND BREAKS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | GENOMIC INSTABILITY | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | P53 | - |
dc.identifier.url | https://aacrjournals.org/mcr/article/13/2/319/135494/TGF-1-Protects-Cells-from-IR-by-Enhancing-the | - |
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