Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with gram-positive or gram-negative bacteria
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Febus, Raymond | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-07-07T07:44:50Z | - |
dc.date.available | 2022-07-07T07:44:50Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-11 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143972 | - |
dc.description.abstract | Innate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host-pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with gram-positive or gram-negative bacteria | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1080/19768354.2014.972981 | - |
dc.identifier.scopusid | 2-s2.0-84919844355 | - |
dc.identifier.wosid | 000346581000006 | - |
dc.identifier.bibliographicCitation | ANIMAL CELLS AND SYSTEMS, v.18, no.6, pp.394 - 398 | - |
dc.relation.isPartOf | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.title | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 394 | - |
dc.citation.endPage | 398 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001938357 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | STRESS-RESPONSE | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | FERTILITY | - |
dc.subject.keywordPlus | CALNEXIN | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | HOST | - |
dc.subject.keywordAuthor | calcineurin | - |
dc.subject.keywordAuthor | calreticulin | - |
dc.subject.keywordAuthor | innate immunity | - |
dc.subject.keywordAuthor | calnexin | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/19768354.2014.972981 | - |
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