Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Lim, Yunki | - |
dc.contributor.author | Lee, Dukgyu | - |
dc.contributor.author | Kalichamy, Karunambigai | - |
dc.contributor.author | Hong, Seong-Eui | - |
dc.contributor.author | Michalak, Marek | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.contributor.author | Kim, Do Han | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.date.accessioned | 2022-07-07T13:32:06Z | - |
dc.date.available | 2022-07-07T13:32:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1357-2725 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144575 | - |
dc.description.abstract | Excessive accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen causes ER stress, which induces a set of genes, including those encoding ER-resident chaperones, to relieve the detrimental effects and recover homeostasis. Calreticulin is a chaperone that facilitates protein folding in the ER lumen, and its gene expression is induced by ER stress in Caenorhabditis elegans. Sumoylation conjugates small ubiquitin-like modifier (SUMO) proteins with target proteins to regulate a variety of biological processes, such as protein stability, nuclear transport, DNA binding, and gene expression. In this study, we showed that C elegans X-box-binding protein 1 (Ce-XBP-1), an ER stress response transcription factor, interacts with the SUMO-conjugating enzyme UBC-9 and a SUMOylation target. Our results indicated that abolishing sumoylation enhanced calreticulin expression in an XBP-1-dependent manner, and the resulting increase in calreticulin counteracted ER stress. Furthermore, sumoylation was repressed in C. elegans undergoing ER stress. Finally, RNAi against ubc-9 mainly affected the expression of genes associated with ER functions, such as lipid and organic acid metabolism. Our results suggest that sumoylation plays a regulatory role in ER function by controlling the expression of genes required for ER homeostasis in C elegans. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1016/j.biocel.2014.06.005 | - |
dc.identifier.scopusid | 2-s2.0-84903526398 | - |
dc.identifier.wosid | 000340340400046 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, v.53, pp.399 - 408 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | - |
dc.citation.volume | 53 | - |
dc.citation.startPage | 399 | - |
dc.citation.endPage | 408 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | SUMO | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | SMT3 | - |
dc.subject.keywordPlus | XBP1 | - |
dc.subject.keywordAuthor | Sumoylation | - |
dc.subject.keywordAuthor | XBP-1 | - |
dc.subject.keywordAuthor | UBC-9 | - |
dc.subject.keywordAuthor | Calreticulin | - |
dc.subject.keywordAuthor | ER stress | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1357272514002039?via%3Dihub | - |
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