The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mi-Ran | - |
dc.contributor.author | Lim, Chae-ji | - |
dc.contributor.author | Lee, You-Han | - |
dc.contributor.author | Park, Jong-Gil | - |
dc.contributor.author | Sonn, Seong Keun | - |
dc.contributor.author | Lee, Mi-Ni | - |
dc.contributor.author | Jung, In-Hyuk | - |
dc.contributor.author | Jeong, Se-Jin | - |
dc.contributor.author | Jeon, Sejin | - |
dc.contributor.author | Lee, Myoungsook | - |
dc.contributor.author | Oh, Ki Sook | - |
dc.contributor.author | Yang, Young | - |
dc.contributor.author | Kim, Jae Bum | - |
dc.contributor.author | Choi, Hueng-Sik | - |
dc.contributor.author | Jeong, Woojin | - |
dc.contributor.author | Jeong, Tae-Sook | - |
dc.contributor.author | Yoon, Won Kee | - |
dc.contributor.author | Kim, Hyoung Chin | - |
dc.contributor.author | Choi, Jae-Hoon | - |
dc.contributor.author | Oh, Goo Taeg | - |
dc.date.accessioned | 2022-07-07T13:33:11Z | - |
dc.date.available | 2022-07-07T13:33:11Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144602 | - |
dc.description.abstract | Hyperlipidemia is a well-recognized risk factor for atherosclerosis and can be regulated by adipokines. Expression of the adipokine resistin-like molecule alpha (Retnla) is regulated by food intake; whether Retnla has a role in the pathogenesis of hyperlipidemia and atherosclerosis is unknown. Here we report that Retnla has a cholesterol-lowering effect and protects against atherosclerosis in low-density lipoprotein receptor-deficient mice. On a high-fat diet, Retnla deficiency promotes hypercholesterolaemia and atherosclerosis, whereas Retnla overexpression reverses these effects and improves the serum lipoprotein profile, with decreased cholesterol in the very low-density lipoprotein fraction concomitant with reduced serum apolipoprotein B levels. We show that Retnla upregulates cholesterol-7-alpha-hydroxylase, a key hepatic enzyme in the cholesterol catabolic pathway, through induction of its transcriptional activator liver receptor homologue-1, leading to increased excretion of cholesterol in the form of bile acids. These findings define Retnla as a novel therapeutic target for treating hypercholesterolaemia and atherosclerosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | The adipokine Retnla modulates cholesterol homeostasis in hyperlipidemic mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jae-Hoon | - |
dc.identifier.doi | 10.1038/ncomms5410 | - |
dc.identifier.scopusid | 2-s2.0-84904479931 | - |
dc.identifier.wosid | 000340622900002 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, v.5, pp.1 - 15 | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.citation.title | NATURE COMMUNICATIONS | - |
dc.citation.volume | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RESISTIN-LIKE-MOLECULE | - |
dc.subject.keywordPlus | BILE-ACID SYNTHESIS | - |
dc.subject.keywordPlus | INDUCED INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | E-DEFICIENT MICE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | TYPE-2 INFLAMMATION | - |
dc.subject.keywordPlus | PROMOTES ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | TRANSGENIC EXPRESSION | - |
dc.subject.keywordPlus | NUCLEAR RECEPTORS | - |
dc.identifier.url | https://www.nature.com/articles/ncomms5410 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.