Effects of Postnatal Dexamethasone or Hydrocortisone in a Rat Model of Antenatal Lipopolysaccharide and Neonatal Hyperoxia Exposure
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyun Ju | - |
dc.contributor.author | Kim, Beyong Il | - |
dc.contributor.author | Choi, Eung Sang | - |
dc.contributor.author | Choi, Chang Won | - |
dc.contributor.author | Kim, Ee-Kyung | - |
dc.contributor.author | Kim, Han-Suk | - |
dc.contributor.author | Choi, Jung-Hwan | - |
dc.date.accessioned | 2022-07-07T14:02:18Z | - |
dc.date.available | 2022-07-07T14:02:18Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144778 | - |
dc.description.abstract | The aim of our study was to investigate the differential effects of dexamethasone (DXM) and hydrocortisone (HCS) on somatic growth and postnatal lung development in a rat model of bronchopulmonary dysplasia (BPD). A rat model of BPD was induced by administering intra-amniotic lipopolysaccharide (LPS) and postnatal hyperoxia. The rats were treated with a 6-day (D1-D6) tapering course of DXM (starting dose 0.5 mg/kg/day), HCS (starting dose 2 mg/kg/day), or an equivalent volume of normal saline. DXM treatment in a rat model of BPD induced by LPS and hyperoxia was also associated with a more profound weight loss compared to control and LPS + O-2 groups not exposed to corticosteroid, whereas HCS treatment affected body weight only slightly. Examination of lung morphology showed worse mean cord length in both LPS + O-2 + DXM and LPS + O-2 + HCS groups as compared to the LPS + O-2 alone group, and the LPS + O-2 + DXM group had thicker alveolar walls than the LPS + O-2 group at day 14. The HCS treatment was not significantly associated with aberrant alveolar wall thickening and retarded somatic growth. The use of postnatal DXM or HCS in a rat model of BPD induced by intra-amniotic LPS and postnatal hyperoxia appeared detrimental to lung growth, but there was less effect in the case of HCS. These findings suggest that effect of HCS on somatic growth and pulmonary outcome may be better tolerated in neonates for preventing and/or treating BPD. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Effects of Postnatal Dexamethasone or Hydrocortisone in a Rat Model of Antenatal Lipopolysaccharide and Neonatal Hyperoxia Exposure | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Hyun Ju | - |
dc.identifier.doi | 10.3346/jkms.2012.27.4.395 | - |
dc.identifier.scopusid | 2-s2.0-84862867729 | - |
dc.identifier.wosid | 000302588800010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.4, pp.395 - 401 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 401 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.identifier.kciid | ART001650269 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | EARLY ADRENAL INSUFFICIENCY | - |
dc.subject.keywordPlus | CHRONIC LUNG-DISEASE | - |
dc.subject.keywordPlus | BRONCHOPULMONARY DYSPLASIA | - |
dc.subject.keywordPlus | PRETERM INFANTS | - |
dc.subject.keywordPlus | OXYGEN-TOXICITY | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | GLUCOCORTICOIDS | - |
dc.subject.keywordPlus | CORTICOSTEROIDS | - |
dc.subject.keywordPlus | PROPHYLAXIS | - |
dc.subject.keywordPlus | MEDIATORS | - |
dc.subject.keywordAuthor | Bronchopulmonary dysplasia | - |
dc.subject.keywordAuthor | Dexamethasone | - |
dc.subject.keywordAuthor | Hydrocortisone | - |
dc.subject.keywordAuthor | Lung development | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2012.27.4.395 | - |
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