Comparison of polyphenol-rich wine grape seed flour-regulated fecal and blood microRNAs in high-fat, high-fructose diet-induced obese mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Kun-Ho | - |
dc.contributor.author | Yokoyama, Wallace | - |
dc.contributor.author | Kim, Hyunsook | - |
dc.date.accessioned | 2022-07-07T14:34:01Z | - |
dc.date.available | 2022-07-07T14:34:01Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144995 | - |
dc.description.abstract | A biomarker, easily and noninvasively measured in feces, can be useful in monitoring efficacy of novel functional foods against complicated pathologies of obesity-related metabolic diseases. Fecal microRNA (miRNA)s were analyzed for potential noninvasive biomarkers in C57BL/6J mice fed a high-fat and high-fructose diet (HFrD) containing either microcrystalline cellulose (MCC) or 5% polyphenol-rich wine grape seed flour (GSF) for 8 weeks. GSF supplementation significantly reduced HFrD-induced body weight gain, visceral adiposity, and hyperlipidemia. miRNome analysis revealed that GSF supplementation significantly (p < 0.05; fold-change, |FC| ≥ 1.5) regulated 82 and 4 miRNAs in the feces and blood, respectively. Among these miRNAs, 22 in feces and 4 in blood were strongly associated with obesity-related physiological biomarkers, and miR-129-5p in both blood and feces showed a strong correlation with obesity-related biomarkers. These results suggest that fecal miR-129-5p is a potentially useful noninvasive biomarker in monitoring personalized GSF efficacy against obesity and obesity-metabolic disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.title | Comparison of polyphenol-rich wine grape seed flour-regulated fecal and blood microRNAs in high-fat, high-fructose diet-induced obese mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunsook | - |
dc.identifier.doi | 10.1016/j.jff.2020.104147 | - |
dc.identifier.scopusid | 2-s2.0-85089265562 | - |
dc.identifier.wosid | 000579501700009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.73, pp.1 - 7 | - |
dc.relation.isPartOf | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 73 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SUPPLEMENTATION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | miRNA biomarker | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Feces | - |
dc.subject.keywordAuthor | Blood | - |
dc.subject.keywordAuthor | Polyphenol | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1756464620303716?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.