Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Kwon, Mi Jung | - |
dc.contributor.author | Ra, Yong Joon | - |
dc.contributor.author | Lee, Hee Sung | - |
dc.contributor.author | Kim, Hyoung Soo | - |
dc.contributor.author | Nam, Eun Sook | - |
dc.contributor.author | Cho, Seong Jin | - |
dc.contributor.author | Park, Hye-Rim | - |
dc.contributor.author | Min, Soo Kee | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Choe, Ji-Young | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Kang, So Young | - |
dc.date.accessioned | 2022-07-07T14:34:53Z | - |
dc.date.available | 2022-07-07T14:34:53Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 1746-1596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145028 | - |
dc.description.abstract | Background: Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target.PIK3CA,KRAS, andBRAFmutations, microsatellite instability (MSI) caused by deficient mismatch repair (dMMR), and human papillomavirus (HPV) can potentially upregulate PD-L1 expression, which might contribute to the clinical outcome of patients with ESCC. Methods: We investigated the significance of the present druggable markers [PD-L1,PIK3CA,KRAS, andBRAFmutations, MSI caused by deficient dMMR, and HPV] in 64 curatively resected ESCCs, using immunohistochemistry (PD-L1 and MMR protein expression), direct sequencing (KRAS,BRAF, andPIK3CAmutations), real-time PCR (HPV infection), and MSI using quasi-monomorphic markers. Results: PD-L1 expression,PIK3CAmutation, and MSI/dMMR were detected in 35.9, 12.5, and 17.2% of ESCCs, respectively. HPV was rarely detected (1.6%) (high-risk HPV68), whereasKRASandBRAFmutations were not detected in ESCCs. PD-L1-positive tumors were not correlated withPIK3CAmutation or MSI/dMMR (allP > 0.05). PD-L1,PIK3CAmutation, and MSI/dMMR characterized the patients associated with light smoking, female and younger age, and younger age and well-differentiated tumors, respectively (allP < 0.05). In multivariate analysis, only PD-L1-positivity was an independent favorable prognostic factor for overall survival (OS) and disease-free survival (DFS) (P = 0.023,P = 0.014). In the PD-L1-negative ESCCs,PIK3CAmutation had a poor prognostic impact on both OS and DFS (P = 0.006,P = 0.002). Conclusions: PIK3CAmutation may be an alternative prognostic biomarker in PD-L1-negative curatively resected ESCCs that can be optional to identify high-risk patients with worse clinical outcome who require more intensive therapy and follow-up. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.title | Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.identifier.doi | 10.1186/s13000-020-01045-4 | - |
dc.identifier.scopusid | 2-s2.0-85092667296 | - |
dc.identifier.wosid | 000581475400001 | - |
dc.identifier.bibliographicCitation | DIAGNOSTIC PATHOLOGY, v.15, no.1, pp.1 - 12 | - |
dc.relation.isPartOf | DIAGNOSTIC PATHOLOGY | - |
dc.citation.title | DIAGNOSTIC PATHOLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | PROGRAMMED DEATH LIGAND-1 | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | FAVORABLE PROGNOSIS | - |
dc.subject.keywordPlus | CANCER-PATIENTS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordAuthor | Programmed death-ligand 1 | - |
dc.subject.keywordAuthor | Esophagus | - |
dc.subject.keywordAuthor | Squamous cell carcinoma | - |
dc.subject.keywordAuthor | Microsatellite instability | - |
dc.subject.keywordAuthor | Human papillomavirus | - |
dc.subject.keywordAuthor | PIK3CA | - |
dc.identifier.url | https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-01045-4 | - |
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