Association between shift work and biological factors including FGF-23, klotho, and serum 25-(OH) vitamin D-3 among Korean firefighters: a cross-sectional study
DC Field | Value | Language |
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dc.contributor.author | Min, Jeehee | - |
dc.contributor.author | Jang, Tae-Won | - |
dc.contributor.author | Ahn, Yeon Soon | - |
dc.contributor.author | Sim, Chang Sun | - |
dc.contributor.author | Jeong, Kyoung Sook | - |
dc.date.accessioned | 2022-07-07T14:38:17Z | - |
dc.date.available | 2022-07-07T14:38:17Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0161-8105 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145071 | - |
dc.description.abstract | Study Objectives: Shift work is known to be detrimental to an individual's health as it disrupts the circadian rhythm and is a risk factor for cancer. It has been reported that elevated fibroblast growth factor (FGF)-23, increased serum soluble alpha-klotho, and decreased vitamin D-3 are associated with cancer progression. We studied the relationship between shift work and the levels of FGF-23, alpha-klotho, and vitamin D-3 amongst firefighters, as they work in long shifts outside the traditional daytime schedule. Methods: The study consisted of 450 participants who were firefighters. We measured FGF-23, alpha-klotho, and vitamin D-3 levels in their blood and a set of questionnaires were given to the participants to evaluate their health habits. After determining and adjusting for potential confounding factors, we compared the levels of FGF-23, alpha-ldotho, and serum vitamin D-3 by job and shift types. Results: FGF-23 and alpha-klotho levels were significantly higher in shift workers than traditional day workers, and in 3-day cycle shift workers than workers with another shift schedule. When the levels of these substances were compared based on different types of jobs, firefighters had a lower level of vitamin D-3. We conclude that shift work is positively correlated with the levels of FGF-23 and alpha-klotho. Conclusions: Levels of FGF-23 and alpha-klotho were linked to shift work and job types. Although vitamin levels did not differ by shift types, vitamin D-3 levels were lower in firefighters. These findings suggest that high levels of FGF-23 and alpha-klotho are potential risk factors for cancer among firefighters. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Association between shift work and biological factors including FGF-23, klotho, and serum 25-(OH) vitamin D-3 among Korean firefighters: a cross-sectional study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Tae-Won | - |
dc.identifier.doi | 10.1093/sleep/zsaa075 | - |
dc.identifier.scopusid | 2-s2.0-85096685898 | - |
dc.identifier.wosid | 000593473600011 | - |
dc.identifier.bibliographicCitation | SLEEP, v.43, no.10, pp.1 - 8 | - |
dc.relation.isPartOf | SLEEP | - |
dc.citation.title | SLEEP | - |
dc.citation.volume | 43 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | NIGHT WORK | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | FGF23 | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | MODULATOR | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | CATENIN | - |
dc.subject.keywordAuthor | Klotho | - |
dc.subject.keywordAuthor | fibroblast growth factor | - |
dc.subject.keywordAuthor | vitamin D3 | - |
dc.subject.keywordAuthor | 25-(OH) vitamin | - |
dc.subject.keywordAuthor | shift work | - |
dc.subject.keywordAuthor | firefighter | - |
dc.identifier.url | https://academic.oup.com/sleep/article/43/10/zsaa075/5826751 | - |
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