Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression
DC Field | Value | Language |
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dc.contributor.author | Kim, Gi Jeong | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.contributor.author | Chae, Seoung Wan | - |
dc.contributor.author | Kim, Se Hoon | - |
dc.contributor.author | Son, Byoung Kwan | - |
dc.contributor.author | Moon, Kyoung Min | - |
dc.contributor.author | Kim, Young Hwan | - |
dc.date.accessioned | 2022-07-07T17:31:00Z | - |
dc.date.available | 2022-07-07T17:31:00Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1541-2016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145309 | - |
dc.description.abstract | Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P=0.010) as well as diminished disease-free survival rate (P=0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival;P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Kyueng-Whan | - |
dc.identifier.doi | 10.1097/PAI.0000000000000795 | - |
dc.identifier.scopusid | 2-s2.0-85069692558 | - |
dc.identifier.wosid | 000570235200014 | - |
dc.identifier.bibliographicCitation | APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, v.28, no.7, pp.544 - 550 | - |
dc.relation.isPartOf | APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | - |
dc.citation.title | APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY | - |
dc.citation.volume | 28 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 544 | - |
dc.citation.endPage | 550 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anatomy & Morphology | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Anatomy & Morphology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | HISTONE VARIANTS | - |
dc.subject.keywordPlus | DEMETHYLASE UTX | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | UTX | - |
dc.subject.keywordAuthor | MMP-11 | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | molecular classification | - |
dc.identifier.url | https://journals.lww.com/appliedimmunohist/Fulltext/2020/08000/Expression_of_UTX_Indicates_Poor_Prognosis_in.10.aspx | - |
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