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Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study

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dc.contributor.authorKim, Kyu Shik-
dc.contributor.authorJeong, Tae Yoong-
dc.contributor.authorMoon, Hong Sang-
dc.date.accessioned2022-07-08T01:06:14Z-
dc.date.available2022-07-08T01:06:14Z-
dc.date.created2021-05-12-
dc.date.issued2020-06-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145600-
dc.description.abstractErectile dysfunction (ED) and depression are closely related. We sought to determine ED and depression were improved by tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, at 5 mg daily, in this case–control study. Participants were men aged 20 to 65 years with ED for >3 months, International Index of Erectile Function-5 (IIEF) score <21 points, and Zung Self-Rating Depression Scale (SDS) survey result >50 points who were willing to participate. On first visit (V1) and after 1 (V2) and 2 months (V3), clinical features were examined using IIEF-5 for diagnosing and evaluating ED, SDS for evaluating depression, and International Prostate Symptom Score and Quality of Life (IPSS/QoL) survey for examining lower urinary tract symptoms (LUTS). Tadalafil 5 mg was administered daily for 2 months. A total of 60 participants were an average age of 58.68 ± 6.71 years. Patient overall average IIEF was 8.76 ± 5.98, showing mild ED symptoms, and total average IPSS 13.74 ± 7.55 showed moderate LUTS. Average overall SDS index was 58.93 ± 9.21, indicating moderate-to-severe findings. Average change in IIEF among all patients revealed significant improvement from V1 to V2 (−2.69 ± 1.22, P = .03) and V1 to V3 (−4.38 ± 1.20, P < 0.01). IPSS also significantly improved from V1 to V3 (3.48 ± 1.37, P = .01), as did SDS index (V1, V2: 4.69 ± 1.89, P = 0.02), (V1, V3: 5.43 ± 1.89, P < .01). Patients with severe IIEF scores (group 1, n = 27) experienced significantly greater improvement in IIEF from V1 to V2 and V1 and V3, compared to those with mild-to-moderate IIEF scores. Both groups improved in SDS index from V1 to V2 and V1 to V3, with the greatest improvement between V1 and V3 for group 1 and V1 and V2 for group 2. Daily tadalafil 5 mg could be helpful for ED patients with depressive symptoms and improved LUTS and quality of life.-
dc.language영어-
dc.language.isoen-
dc.publisherLIPPINCOTT WILLIAMS & WILKINS-
dc.titleEffect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Kyu Shik-
dc.contributor.affiliatedAuthorMoon, Hong Sang-
dc.identifier.doi10.1097/MD.0000000000020546-
dc.identifier.scopusid2-s2.0-85086008128-
dc.identifier.wosid000549892300054-
dc.identifier.bibliographicCitationMEDICINE, v.99, no.23, pp.1 - 6-
dc.relation.isPartOfMEDICINE-
dc.citation.titleMEDICINE-
dc.citation.volume99-
dc.citation.number23-
dc.citation.startPage1-
dc.citation.endPage6-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGeneral & Internal Medicine-
dc.relation.journalWebOfScienceCategoryMedicine, General & Internal-
dc.subject.keywordPlusNOCTURNAL PENILE TUMESCENCE-
dc.subject.keywordPlusSILDENAFIL CITRATE-
dc.subject.keywordPlusMEN-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusMANAGEMENT-
dc.subject.keywordPlusLIFE-
dc.subject.keywordAuthordepression-
dc.subject.keywordAuthorerectile dysfunction-
dc.subject.keywordAuthorphosphodiesterase 5 inhibitors-
dc.identifier.urlhttps://journals.lww.com/md-journal/Fulltext/2020/06050/Effect_of_daily_tadalafil_on_reported_outcomes_in.55.aspx-
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