Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyu Shik | - |
dc.contributor.author | Jeong, Tae Yoong | - |
dc.contributor.author | Moon, Hong Sang | - |
dc.date.accessioned | 2022-07-08T01:06:14Z | - |
dc.date.available | 2022-07-08T01:06:14Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145600 | - |
dc.description.abstract | Erectile dysfunction (ED) and depression are closely related. We sought to determine ED and depression were improved by tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, at 5 mg daily, in this case–control study. Participants were men aged 20 to 65 years with ED for >3 months, International Index of Erectile Function-5 (IIEF) score <21 points, and Zung Self-Rating Depression Scale (SDS) survey result >50 points who were willing to participate. On first visit (V1) and after 1 (V2) and 2 months (V3), clinical features were examined using IIEF-5 for diagnosing and evaluating ED, SDS for evaluating depression, and International Prostate Symptom Score and Quality of Life (IPSS/QoL) survey for examining lower urinary tract symptoms (LUTS). Tadalafil 5 mg was administered daily for 2 months. A total of 60 participants were an average age of 58.68 ± 6.71 years. Patient overall average IIEF was 8.76 ± 5.98, showing mild ED symptoms, and total average IPSS 13.74 ± 7.55 showed moderate LUTS. Average overall SDS index was 58.93 ± 9.21, indicating moderate-to-severe findings. Average change in IIEF among all patients revealed significant improvement from V1 to V2 (−2.69 ± 1.22, P = .03) and V1 to V3 (−4.38 ± 1.20, P < 0.01). IPSS also significantly improved from V1 to V3 (3.48 ± 1.37, P = .01), as did SDS index (V1, V2: 4.69 ± 1.89, P = 0.02), (V1, V3: 5.43 ± 1.89, P < .01). Patients with severe IIEF scores (group 1, n = 27) experienced significantly greater improvement in IIEF from V1 to V2 and V1 and V3, compared to those with mild-to-moderate IIEF scores. Both groups improved in SDS index from V1 to V2 and V1 to V3, with the greatest improvement between V1 and V3 for group 1 and V1 and V2 for group 2. Daily tadalafil 5 mg could be helpful for ED patients with depressive symptoms and improved LUTS and quality of life. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Effect of daily tadalafil on reported outcomes in patients with erectile dysfunction and depressive symptoms STROBE, a case-control study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Shik | - |
dc.contributor.affiliatedAuthor | Moon, Hong Sang | - |
dc.identifier.doi | 10.1097/MD.0000000000020546 | - |
dc.identifier.scopusid | 2-s2.0-85086008128 | - |
dc.identifier.wosid | 000549892300054 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.99, no.23, pp.1 - 6 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 99 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | NOCTURNAL PENILE TUMESCENCE | - |
dc.subject.keywordPlus | SILDENAFIL CITRATE | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | erectile dysfunction | - |
dc.subject.keywordAuthor | phosphodiesterase 5 inhibitors | - |
dc.identifier.url | https://journals.lww.com/md-journal/Fulltext/2020/06050/Effect_of_daily_tadalafil_on_reported_outcomes_in.55.aspx | - |
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