A single-cell survey of Drosophila blood
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tattikota, Sudhir Gopal | - |
dc.contributor.author | Cho, Bumsik | - |
dc.contributor.author | Liu, Yifang | - |
dc.contributor.author | Hu, Yanhui | - |
dc.contributor.author | Barrera, Victor | - |
dc.contributor.author | Steinbaugh, Michael J. | - |
dc.contributor.author | Yoon, Sang-Ho | - |
dc.contributor.author | Comjean, Aram | - |
dc.contributor.author | Li, Fangge | - |
dc.contributor.author | Dervis, Franz | - |
dc.contributor.author | Hung, Ruei-Jiun | - |
dc.contributor.author | Nam, Jin-Wu | - |
dc.contributor.author | Sui, Shannan Ho | - |
dc.contributor.author | Shim, Jiwon | - |
dc.contributor.author | Perrimon, Norbert | - |
dc.date.accessioned | 2022-07-08T04:35:41Z | - |
dc.date.available | 2022-07-08T04:35:41Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145772 | - |
dc.description.abstract | Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal cells, and lamellocytes based on the expression of a few marker genes and cell morphologies, which are inadequate to classify the complete hemocyte repertoire. Here, we used single-cell RNA sequencing (scRNA-seq) to map hemocytes across different inflammatory conditions in larvae. We resolved plasmatocytes into different states based on the expression of genes involved in cell cycle, antimicrobial response, and metabolism together with the identification of intermediate states. Further, we discovered rare subsets within crystal cells and lamellocytes that express fibroblast growth factor (FGF) ligand branchless and receptor breathless, respectively. We demonstrate that these FGF components are required for mediating effective immune responses against parasitoid wasp eggs, highlighting a novel role for FGF signaling in inter-hemocyte crosstalk. Our scRNA-seq analysis reveals the diversity of hemocytes and provides a rich resource of gene expression profiles for a systems-level understanding of their functions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD | - |
dc.title | A single-cell survey of Drosophila blood | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Nam, Jin-Wu | - |
dc.contributor.affiliatedAuthor | Shim, Jiwon | - |
dc.identifier.doi | 10.7554/eLife.54818 | - |
dc.identifier.scopusid | 2-s2.0-85084939233 | - |
dc.identifier.wosid | 000535314900001 | - |
dc.identifier.bibliographicCitation | ELIFE, v.9, pp.1 - 35 | - |
dc.relation.isPartOf | ELIFE | - |
dc.citation.title | ELIFE | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 35 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | HEMATOPOIETIC STEM | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | RIBOSOMAL-RNA | - |
dc.subject.keywordPlus | CYCLE EXIT | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HEMOCYTES | - |
dc.subject.keywordPlus | REVEALS | - |
dc.identifier.url | https://elifesciences.org/articles/54818 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.