Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Hye Ree | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.contributor.author | Yang, Seung | - |
dc.date.accessioned | 2022-07-08T09:22:23Z | - |
dc.date.available | 2022-07-08T09:22:23Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2287-1012 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145982 | - |
dc.description.abstract | Purpose: This study evaluated the -202 A/C insulin-like growth factor binding protein 3 (IGFBP-3) promoter polymorphism as a predictor of serum IGFBP-3 concentration and growth velocity after recombinant growth hormone (rhGH) therapy in patients with idiopathic short stature (ISS). Methods: Genotyping and serial measurement of clinical parameters were performed in 69 children with a confirmed diagnosis of ISS. Restriction fragment length polymorphism analysis was performed to determine the genotype at the -202 IGFBP-3 locus. Serum insulin-like growth factor 1 (IGF-1) and IGFBP-3 levels were measured at baseline and after 1 year of rhGH treatment, as were height standard deviation score and growth velocity. Results: The -202 A/C IGFBP-3 genotype comprised 69.6% AA, 24.6% AC, and 5.8% CC. One year of treatment did not produce a meaningful difference in IGF-1 or IGFBP-3 levels between children in the AA group and those with at least one copy of the C allele (AC/CC group). Comparing the 2 groups after one year also revealed no significant difference in growth velocity (Delta Height: 9.061 +/- 1.612 cm/yr in the (Delta A group, 9.421 +/- 1.864 in the AC/CC group, P=0.419). Conclusion: rhGH treatment was effective and there were no significant differences in IGF-1, IGFBP-3, or growth velocity according to genotype. Thus, -202 IGFBP-3 genotype may not be a major factor affecting individual growth responses in Korean children with ISS. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PEDIATRIC ENDOCRINOLOGY | - |
dc.title | Effect of -202 A/C IGFBP-3 polymorphisms on growth responses in children with idiopathic short stature | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yang, Seung | - |
dc.identifier.doi | 10.6065/apem.2020.25.1.31 | - |
dc.identifier.scopusid | 2-s2.0-85084001241 | - |
dc.identifier.wosid | 000522789200005 | - |
dc.identifier.bibliographicCitation | ANNALS OF PEDIATRIC ENDOCRINOLOGY&METABOLISM, v.25, no.1, pp.31 - 37 | - |
dc.relation.isPartOf | ANNALS OF PEDIATRIC ENDOCRINOLOGY&METABOLISM | - |
dc.citation.title | ANNALS OF PEDIATRIC ENDOCRINOLOGY&METABOLISM | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 37 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | FACTOR-BINDING PROTEIN-3 | - |
dc.subject.keywordPlus | FACTOR-I | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
dc.subject.keywordPlus | PREPUBERTAL CHILDREN | - |
dc.subject.keywordPlus | HORMONE DEFICIENCY | - |
dc.subject.keywordPlus | ADULT HEIGHT | - |
dc.subject.keywordPlus | CANCER RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | GH | - |
dc.subject.keywordAuthor | Insulin-like growth factor binding protein 3 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Idiopathic short stature | - |
dc.subject.keywordAuthor | Growth hormone | - |
dc.identifier.url | https://e-apem.org/journal/view.php?doi=10.6065/apem.2020.25.1.31 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.