Beneficial effect of statin on preventing contrast-induced acute kidney injury in patients with renal insufficiency A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Cho, AJin | - |
dc.contributor.author | Lee, Young-Ki | - |
dc.contributor.author | Sohn, Seo Young | - |
dc.date.accessioned | 2022-07-08T09:27:58Z | - |
dc.date.available | 2022-07-08T09:27:58Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146069 | - |
dc.description.abstract | Background: Renal insufficiency is an important predictor of contrast-induced acute kidney injury (CI-AKI). We performed a meta-analysis to examine the effects of short-term statin therapy on the incidence of CI-AKI, particularly in patients with renal insufficiency. Methods: A systematic search was conducted to retrieve randomized controlled trials (RCTs) that investigated the impact of statin pretreatment before administration of contrast media on the development of CI-AKI in patients with mild to moderate renal insufficiency. The primary outcome was development of CI-AKI. The secondary outcome was the incidence ofacute kidney injury requiring hemodialysis. Results: Data analysis from 8 RCTs, which included a total of 2313 subjects in the statin-treated group and 2322 in the control group, showed that statin pretreatment was associated with significant reduction of the risk of CI-AKI (relative risk [RR] = 0.59; 95% confidential interval [CI] 0.44–0.79; P = .0003, I2 = 0%). A beneficial effect of statin on preventing CI-AKI was consistent, regardless of the dose of statin and use of N-acetylcysteine. In subgroup analysis based on baseline estimated glomerular filtration rate (eGFR), patients with baseline eGFR <60 mL/min/1.73 m2 (RR = 0.63; 95% CI 0.41–0.98; P = .04, I2 = 0%) and 30 < eGFR < 90 mL/min/1.73 m2 (RR = 0.56; 95% CI 0.39–0.82; P = .003, I2 = 0%) showed significant reduction of risk of CI-AKI. Conclusion: Statin pretreatment is effective at preventing CI-AKI and should be considered in patients with preexisting renal insufficiency. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Beneficial effect of statin on preventing contrast-induced acute kidney injury in patients with renal insufficiency A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Sohn, Seo Young | - |
dc.identifier.doi | 10.1097/MD.0000000000019473 | - |
dc.identifier.scopusid | 2-s2.0-85081632348 | - |
dc.identifier.wosid | 000525051700065 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.99, no.10, pp.1 - 8 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 99 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | INDUCED NEPHROPATHY | - |
dc.subject.keywordPlus | ROSUVASTATIN | - |
dc.subject.keywordPlus | ATORVASTATIN | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | INTERVENTIONS | - |
dc.subject.keywordPlus | ANGIOGRAPHY | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | contrast media | - |
dc.subject.keywordAuthor | statin | - |
dc.identifier.url | https://journals.lww.com/md-journal/Fulltext/2020/03060/Beneficial_effect_of_statin_on_preventing.65.aspx | - |
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