Transition-Metal-Catalyzed Annulative Coupling Cascade for the Synthesis of 3-Methyleneisoindolin-1-ones
- Authors
- Youn, So Won
- Issue Date
- Mar-2020
- Publisher
- GEORG THIEME VERLAG KG
- Keywords
- N-heterocycles; isoindolinones; transition-metal catalysis; C-H functionalization; cascade reactions; cyclizations; coupling reactions
- Citation
- SYNTHESIS-STUTTGART, v.52, no.6, pp.807 - 818
- Indexed
- SCIE
SCOPUS
- Journal Title
- SYNTHESIS-STUTTGART
- Volume
- 52
- Number
- 6
- Start Page
- 807
- End Page
- 818
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146104
- DOI
- 10.1055/s-0039-1690046
- ISSN
- 0039-7881
- Abstract
- This short review describes the recent progress made on transition-metal-catalyzed annulative couplings for the synthesis of 3-methyleneisoindolin-1-ones, which are useful intermediates for the synthesis of numerous alkaloids and can be often found in a wide range of natural products and pharmaceuticals. In particular, new one-pot multiple C-C/C-N bond-forming processes for the construction of the 5-methylenepyrrol-2-one nucleus of such compounds are summarized.
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