Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Prognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma

Full metadata record
DC Field Value Language
dc.contributor.authorJun, Sun-Young-
dc.contributor.authorPark, Eun Su-
dc.contributor.authorLee, Jae Jun-
dc.contributor.authorChang, Hee-Kyung-
dc.contributor.authorJung, Eun Sun-
dc.contributor.authorOh, Young-Ha-
dc.contributor.authorHong, Seung-Mo-
dc.date.accessioned2022-07-08T16:03:19Z-
dc.date.available2022-07-08T16:03:19Z-
dc.date.created2021-05-12-
dc.date.issued2020-01-
dc.identifier.issn0002-9173-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146333-
dc.description.abstractObjectives: Assessment of tumor-infiltrating lymphocytes (TILs) may predict the prognosis and therapeutic benefit of immunotherapy in small intestinal adenocarcinoma (SIAC) patients. Methods: TILs were evaluated in 231 surgically resected SIACs and compared with microsatellite instability (MSI) and clinicopathologic variables. The average number of intraepithelial TILs (iTILs) and the average density of stromal TILs (sTILs) were calculated separately. Results: High iTIL count (>= 2 per high-power field) was associated with MSI-high, whereas high sTIL density (>= 20% on x200 magnification) was not. High iTIL count and high sTIL density were related to distal tumor location, medullary carcinoma, high Crohn-like lymphoid reaction counts, and fewer pancreatic invasions. SIAC patients with high iTIL count or high sTIL density had better survival than those with low values. On multivariate analysis, MSI, high sTIL density, proximal locations, lower N category, and absence of lymphovascular invasions and retroperitoneal seeding were the best independent prognostic predictors. Conclusions: High sTIL density can be used as a prognostic indicator and high iTIL count may provide a basis for the clinical use of targeted immunotherapy in SIAC patients.-
dc.language영어-
dc.language.isoen-
dc.publisherOXFORD UNIV PRESS INC-
dc.titlePrognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma-
dc.typeArticle-
dc.contributor.affiliatedAuthorOh, Young-Ha-
dc.identifier.doi10.1093/ajcp/aqz136-
dc.identifier.scopusid2-s2.0-85076502333-
dc.identifier.wosid000506827800015-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.153, no.1, pp.105 - 118-
dc.relation.isPartOfAMERICAN JOURNAL OF CLINICAL PATHOLOGY-
dc.citation.titleAMERICAN JOURNAL OF CLINICAL PATHOLOGY-
dc.citation.volume153-
dc.citation.number1-
dc.citation.startPage105-
dc.citation.endPage118-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPathology-
dc.relation.journalWebOfScienceCategoryPathology-
dc.subject.keywordPlusPREDICTING MICROSATELLITE INSTABILITY-
dc.subject.keywordPlusSMALL-BOWEL ADENOCARCINOMA-
dc.subject.keywordPlusMISMATCH-REPAIR-
dc.subject.keywordPlusGENETIC ALTERATIONS-
dc.subject.keywordPlusSTANDARDIZED METHOD-
dc.subject.keywordPlusSOLID TUMORS-
dc.subject.keywordPlusCOLON-CANCER-
dc.subject.keywordPlusGASTROINTESTINAL-TRACT-
dc.subject.keywordPlusENDOMETRIAL-
dc.subject.keywordPlusCARCINOMAS-
dc.subject.keywordAuthorSmall intestine-
dc.subject.keywordAuthorAdenocarcinoma-
dc.subject.keywordAuthorMicrosatellite instability-
dc.subject.keywordAuthorLymphocyte-
dc.subject.keywordAuthorTumor-infiltrating-
dc.subject.keywordAuthorMedullary-
dc.subject.keywordAuthorBiomarkers-
dc.subject.keywordAuthorPrognosis-
dc.identifier.urlhttps://academic.oup.com/ajcp/article/153/1/105/5580101-
Files in This Item
Go to Link
Appears in
Collections
서울 의과대학 > 서울 병리학교실 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Oh, Young Ha photo

Oh, Young Ha
COLLEGE OF MEDICINE (DEPARTMENT OF PATHOLOGY)
Read more

Altmetrics

Total Views & Downloads

BROWSE