Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg
DC Field | Value | Language |
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dc.contributor.author | Lee, Seon-yeong | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Seo, Hyeon-Beom | - |
dc.contributor.author | Ryu, Jun-Geol | - |
dc.contributor.author | Jung, KyungAh | - |
dc.contributor.author | Choi, Jeong Won | - |
dc.contributor.author | Jhun, JooYeon | - |
dc.contributor.author | Park, Jin-Sil | - |
dc.contributor.author | Kwon, Ji Ye | - |
dc.contributor.author | Kwok, Seung-Ki | - |
dc.contributor.author | Youn, Jeehee | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.contributor.author | Cho, Mi-La | - |
dc.date.accessioned | 2022-07-08T20:25:39Z | - |
dc.date.available | 2022-07-08T20:25:39Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146641 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is mediated by a chronic and dysregulated inflammatory response. Interleukin (IL)-17, a proinflammatory cytokine, and T helper (Th)17 cells are associated with chronic autoimmune diseases. We hypothesized that inhibition of IL-17 would decrease the numbers of T cell subsets that function as B-cell helpers, as well as B-cell differentiation into plasma cells and autoantibody expression. The IL-17 level was increased markedly in Roquin(san/san) mice. Loss of IL-17 in Roquin(san/san) mice improved nephritis by downregulating immunoglobulin (Ig)G, IgG1, and IgG2a production. Formation of germinal centers (GCs), and follicular B- and T-cell differentiation was reduced, whereas the number of regulatory T (Treg) cells and immature B cells was increased, by IL-17 deficiency in Roquin(san/san) mice. These results suggest that IL-17 inhibition can ameliorate SLE by inhibiting B- cell differentiation into GCs. Therefore, IL-17-producing Th17 cells show promise as a target for development of novel therapeutics for SLE. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Youn, Jeehee | - |
dc.identifier.doi | 10.1038/s41598-019-41534-1 | - |
dc.identifier.scopusid | 2-s2.0-85063498589 | - |
dc.identifier.wosid | 000462300100012 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.9, no.1, pp.1 - 8 | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | HELPER T-CELLS | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | COHORT | - |
dc.identifier.url | https://www.nature.com/articles/s41598-019-41534-1 | - |
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