Clinical impacts of inflammatory markers and clinical factors in patients with relapsed or refractory diffuse large B-cell lymphomaopen access
- Authors
- Kim, Do-Young; Song, Moo-Kon; Chung, Joo-Seop; Shin, Ho-Jin; Yang, Deok Hwan; Lim, Sung-Nam; Oh, Sung-Yong
- Issue Date
- Dec-2019
- Publisher
- KOREAN SOC HEMATOLOGY
- Keywords
- Derived neutrophil/lymphocyte ratio; Glasgow prognostic score; DLBCL
- Citation
- BLOOD RESEARCH, v.54, no.4, pp.244 - 252
- Indexed
- SCOPUS
KCI
- Journal Title
- BLOOD RESEARCH
- Volume
- 54
- Number
- 4
- Start Page
- 244
- End Page
- 252
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146665
- DOI
- 10.5045/br.2019.54.4.244
- ISSN
- 2287-979X
- Abstract
- Background
Systemic inflammatory response can be associated with the prognosis of diffuse large B cell lymphoma (DLBCL). We investigated the systemic factors significantly related to clinical outcome in relapsed/refractory DLBCL.
Methods
In 242 patients with DLBCL, several factors, including inflammatory markers were analyzed. We assessed for the correlation between the survivals [progression-free survival (PFS) and overall survival (OS)] and prognostic factors.
Results
In these patients, a high derived neutrophil/lymphocyte ratio (dNLR) (PFS, HR=2.452, P=0.002; OS, HR=2.542, P=0.005), high Glasgow Prognostic Score (GPS) (PFS, HR=2.435, P=0.002; OS, HR=2.621, P=0.002), and high NCCN-IPI (PFS, HR=2.836, P=0.003; OS, HR=2.928, P=0.003) were significantly associated with survival in multivariate analysis. Moreover, we proposed a risk stratification model based on dNLR, GPS, and NCCN-IPI, thereby distributing patients into 4 risk groups. There were significant differences in survival among the 4 risk groups (PFS, P<0.001; OS, P<0.001).
Conclusion
In conclusion, dNLR, GPS, and NCCN-IPI appear to be excellent prognostic parameters for survival in relapsed/refractory DLBCL.
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