Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hyun-Hee | - |
dc.contributor.author | Han, Myun Hoon | - |
dc.contributor.author | Choi, Ho jin | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Kim, Jae Min | - |
dc.contributor.author | Cheong, Jin Hwan | - |
dc.contributor.author | Ryu, Je Il | - |
dc.contributor.author | Lee, Kyu Yong | - |
dc.contributor.author | Koh, Seong Ho | - |
dc.date.accessioned | 2022-07-09T06:39:22Z | - |
dc.date.available | 2022-07-09T06:39:22Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147086 | - |
dc.description.abstract | Amlodipine, a L-type calcium channel blocker, has been reported to have a neuroprotective effect in brain ischemia. Mitochondrial calcium overload leads to apoptosis of cells in neurologic diseases. We evaluated the neuroprotective effects of amlodipine camsylate (AC) on neural stem cells (NSCs) injured by oxygen glucose deprivation (OGD) with a focus on mitochondrial structure and function. NSCs were isolated from rodent embryonic brains. Effects of AC on cell viability, proliferation, level of free radicals, and expression of intracellular signaling proteins were assessed in OGD-injured NSCs. We also investigated the effect of AC on mitochondrial structure in NSCs under OGD by transmission electron microscopy. AC increased the viability and proliferation of NSCs. This beneficial effect of AC was achieved by strong protection of mitochondria. AC markedly enhanced the expression of mitochondrial biogenesis-related proteins and mitochondrial anti-apoptosis proteins. Together, our results indicate that AC protects OGD-injured NSCs by protecting mitochondrial structure and function. The results of the present study provide insight into the mechanisms underlying the protective effects of AC on NSCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Myun Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Ho jin | - |
dc.contributor.affiliatedAuthor | Lee, Young Joo | - |
dc.contributor.affiliatedAuthor | Kim, Jae Min | - |
dc.contributor.affiliatedAuthor | Cheong, Jin Hwan | - |
dc.contributor.affiliatedAuthor | Ryu, Je Il | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Yong | - |
dc.contributor.affiliatedAuthor | Koh, Seong Ho | - |
dc.identifier.doi | 10.1038/s41598-019-52083-y | - |
dc.identifier.scopusid | 2-s2.0-85074272315 | - |
dc.identifier.wosid | 000493439600015 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9, pp.1 - 11 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NEURONAL CELL-DEATH | - |
dc.subject.keywordPlus | PERMEABILITY TRANSITION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CHANNEL BLOCKER | - |
dc.subject.keywordPlus | REGULATORS | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | BESYLATE | - |
dc.subject.keywordPlus | CA2+ | - |
dc.identifier.url | https://www.nature.com/articles/s41598-019-52083-y | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.