Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction
DC Field | Value | Language |
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dc.contributor.author | Jang, Hyosun | - |
dc.contributor.author | Lee, Janet | - |
dc.contributor.author | Park, Sunhoo | - |
dc.contributor.author | Kim, Joong Sun | - |
dc.contributor.author | Shim, Sehwan | - |
dc.contributor.author | Lee, Seung Bum | - |
dc.contributor.author | Han, Sung-Honn | - |
dc.contributor.author | Myung, Hyunwook | - |
dc.contributor.author | Kim, Hyewon | - |
dc.contributor.author | Jang, Won-Suk | - |
dc.contributor.author | Lee, Sun-Joo | - |
dc.contributor.author | Myung, Jae Kyung | - |
dc.date.accessioned | 2022-07-09T09:35:48Z | - |
dc.date.available | 2022-07-09T09:35:48Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147278 | - |
dc.description.abstract | Background and Aims: Radiation-induced intestinal injury occurred in application of radiotherapy for abdominal and pelvic cancers or in nuclear accidents. Radiation-induced enteritis may be considered an ideal model of gastrointestinal inflammation. The endothelium is a crucial component of inflammation, and the endothelial dysfunction following radiation exposure induces the intestinal proinflammatory response and progression of radiation enteritis. Baicalein (5,6,7-trihydroxyflavonoid) is a flavonoid from Scutellaria baicalensis used in oriental herbal medicine. Baicalein has been found to have multiple beneficial properties including antioxidant, anti-inflammatory, anti-allergic, and anti-cancer activities. Here, we investigated the therapeutic effects of baicalein on endothelial dysfunction in radiation-induced intestinal inflammation. Materials and Methods: We performed histological analysis, bacterial translocation, and intestinal permeability assays and also assessed infiltration of leukocytes and inflammatory cytokine expression using a mouse model of radiation-induced enteritis. In addition, to investigate the effect of baicalein in endothelial dysfunction, we analyzed endothelial-derived adherent molecules in human umbilical vein endothelial cells (HUVECs) and irradiated intestinal tissue. Results: Histological damage such as shortening of villi length and impaired intestinal crypt function was observed in the radiation-induced enteritis mouse model. Intestinal damage was attenuated in baicalein-treated groups with improvement of intestinal barrier function. Baicalein inhibited the expression of radiation-induced adherent molecules in HUVECs and intestine of irradiated mouse and decreased leukocyte infiltration in the radiation-induced enteritis. Conclusions: Baicalein could accelerate crypt regeneration via recovery of endothelial damage. Therefore, baicalein has a therapeutic effect on radiation-induced intestinal inflammation by attenuating endothelial damage. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Baicalein Mitigates Radiation-Induced Enteritis by Improving Endothelial Dysfunction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Myung, Jae Kyung | - |
dc.identifier.doi | 10.3389/fphar.2019.00892 | - |
dc.identifier.scopusid | 2-s2.0-85070910518 | - |
dc.identifier.wosid | 000481429400001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHARMACOLOGY, v.10, pp.1 - 13 | - |
dc.relation.isPartOf | FRONTIERS IN PHARMACOLOGY | - |
dc.citation.title | FRONTIERS IN PHARMACOLOGY | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | BARRIER FUNCTION | - |
dc.subject.keywordPlus | CELL INJURY | - |
dc.subject.keywordPlus | BOWEL | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | EOSINOPHILS | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | baicalein | - |
dc.subject.keywordAuthor | intestinal inflammation | - |
dc.subject.keywordAuthor | endothelial cells | - |
dc.subject.keywordAuthor | adherent molecules | - |
dc.subject.keywordAuthor | irradiation | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fphar.2019.00892/full | - |
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