Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls
DC Field | Value | Language |
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dc.contributor.author | Jeong, Hwal Rim | - |
dc.contributor.author | Lee, Hye Jin | - |
dc.contributor.author | Shim, Yeong Suk | - |
dc.contributor.author | Kang, Min Jae | - |
dc.contributor.author | Yang, Seung | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.date.accessioned | 2022-07-09T09:36:12Z | - |
dc.date.available | 2022-07-09T09:36:12Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 0951-3590 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147282 | - |
dc.description.abstract | This study evaluated the serum level of MKRN3 and investigated its diagnostic usefulness in girls with central precocious puberty (CPP). In total, 41 girls with CPP and 35 age-matched normal control girls were enrolled. Serum values of MKRN3 were measured in both groups. Gonadotropin and estradiol concentrations were evaluated after 6 and 12 months of GnRH agonist (GnRHa) treatment in CPP patients. The MKRN3 concentrations were much lower in the patient group than in the control group (p = .005). Over 1 year of GnRHa treatment in patients, the gonadotropin concentrations were significantly decreased (p < .05), while the MKRN3 concentrations were unchanged (p > .05). MKRN3 levels were inversely correlated to standard deviation (SD) in height (r = −0.46, p = .000), SD in weight (r = −0.32, p = .005), Tanner stage (r = −0.41, p = .000), and bone age (r = −0.46, p = .000). Based on ROC analysis, the area under curve was 0.758 for MKRN3, with 82.9% sensitivity and 68.5% specificity. The measurement of serum MKRN3 level may provide some help for CPP prediction, but relatively various values need further validation | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Serum Makorin ring finger protein 3 values for predicting Central precocious puberty in girls | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yang, Seung | - |
dc.identifier.doi | 10.1080/09513590.2019.1576615 | - |
dc.identifier.scopusid | 2-s2.0-85062366045 | - |
dc.identifier.wosid | 000477899300018 | - |
dc.identifier.bibliographicCitation | GYNECOLOGICAL ENDOCRINOLOGY, v.35, no.8, pp.732 - 736 | - |
dc.relation.isPartOf | GYNECOLOGICAL ENDOCRINOLOGY | - |
dc.citation.title | GYNECOLOGICAL ENDOCRINOLOGY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 732 | - |
dc.citation.endPage | 736 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | MKRN3 LEVELS DECLINE | - |
dc.subject.keywordPlus | PREMATURE THELARCHE | - |
dc.subject.keywordPlus | STIMULATION TEST | - |
dc.subject.keywordPlus | IMPRINTED GENE | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | FREQUENCY | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordPlus | LH | - |
dc.subject.keywordAuthor | Precocious puberty | - |
dc.subject.keywordAuthor | MKRN3 | - |
dc.subject.keywordAuthor | biomarker | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/09513590.2019.1576615 | - |
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