Lactate normalization within 6 hours of bundle therapy and 24 hours of delayed achievement were associated with 28-day mortality in septic shock patients
DC Field | Value | Language |
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dc.contributor.author | Ryoo, Seung Mok | - |
dc.contributor.author | Ahn, Ryeok | - |
dc.contributor.author | Shin, Tae Gun | - |
dc.contributor.author | Jo, You Hwan | - |
dc.contributor.author | Chung, Sung Phil | - |
dc.contributor.author | Beom, Jin Ho | - |
dc.contributor.author | Choi, Sung-Hyuk | - |
dc.contributor.author | Yoon, Young-Hoon | - |
dc.contributor.author | Ko, Byuk Sung | - |
dc.contributor.author | Lee, Hui Jai | - |
dc.contributor.author | Suh, Gil Joon | - |
dc.contributor.author | Kim, Won Young | - |
dc.contributor.author | Park, Yoo Seok | - |
dc.contributor.author | Kim, Kyuseok | - |
dc.contributor.author | Shin, Jong Hwan | - |
dc.contributor.author | Lee, Sung Woo | - |
dc.contributor.author | Kang, Gu Hyun | - |
dc.contributor.author | Lim, Tae Ho | - |
dc.contributor.author | Choi, Han Sung | - |
dc.date.accessioned | 2022-07-09T14:28:09Z | - |
dc.date.available | 2022-07-09T14:28:09Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147700 | - |
dc.description.abstract | This study evaluated the prognostic ability of lactate normalization achieved within 6 and 24 h from septic shock recognition. Data from a septic shock registry from October 2015 to February 2017 were reviewed. The study included 2,102 eligible septic shock patients to analyze the prognostic ability of lactate normalization, defined as a follow-up lactate level <2 mmol/L within six hours of bundle therapy and within 24 hours of delayed normalization. The primary outcome was 28-day mortality. The overall 28-day mortality rate was 21.4%. The rates of lactate normalization within 6 and 24 h were significantly higher in the survivor groups than in the non-survivor group (42.4% vs. 23.4% and 60.2% vs. 31.2%; P<0.001, respectively). Multivariate logistic regression analysis showed that both 6-and 24-h lactate normalization were independent predictors (odds ratio [ OR] 0.58, 95% confidence interval [ CI] 0.45-0.75, p<0.001 and OR 0.42, 95% CI 0.33-0.54, p<0.001, respectively). When we could not achieve the lactate normalization, the sensitivity, specificity, positive, and negative predictive value to predict mortality were 76.6%, 42.4%, 26.5% and 87.0% respectively for 6-h normalization, and 68.8%, 60.2%, 32.0% and 87.7% respectively for 24-h normalization. Besides 6-h lactate normalization, 24-h delayed lactate normalization was associated with decreasing mortality in septic shock patients. Lactate normalization may have a role in early risk stratification and as a therapeutic target. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Lactate normalization within 6 hours of bundle therapy and 24 hours of delayed achievement were associated with 28-day mortality in septic shock patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Byuk Sung | - |
dc.identifier.doi | 10.1371/journal.pone.0217857 | - |
dc.identifier.scopusid | 2-s2.0-85066625115 | - |
dc.identifier.wosid | 000469915700031 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.14, no.6, pp.1 - 10 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | CAMPAIGN INTERNATIONAL GUIDELINES | - |
dc.subject.keywordPlus | GOAL-DIRECTED RESUSCITATION | - |
dc.subject.keywordPlus | CRITICALLY-ILL PATIENTS | - |
dc.subject.keywordPlus | SEVERE SEPSIS | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | CARE | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217857 | - |
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