Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Hang Joon | - |
dc.contributor.author | Kenney-Jung, Daniel L. | - |
dc.contributor.author | Balzekas, Irena | - |
dc.contributor.author | Welker, Kirk M. | - |
dc.contributor.author | Jones, David T | - |
dc.contributor.author | Croarkin, Paul E. | - |
dc.contributor.author | Benarroch, Eduardo E | - |
dc.contributor.author | Worrell, Gregory A. | - |
dc.date.accessioned | 2022-07-09T15:00:09Z | - |
dc.date.available | 2022-07-09T15:00:09Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 1664-2295 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147785 | - |
dc.description.abstract | Background: We compared resting-state functional connectivity (RSFC) among limbic and temporal lobe regions between patients with medial temporal lobe epilepsy (mTLE) and healthy control subjects to identify imaging evidence of functional networks related to seizure frequency, age of seizure onset, and duration of epilepsy. Methods: Twelve patients with drug-resistant, unilateral medial temporal lobe epilepsy and 12 healthy control subjects matched for age, sex, and handedness participated in the imaging experiments. We used network-based statistics to compare functional connectivity graphs in patients with mTLE and healthy controls to investigate the relationship between functional connectivity abnormalities and seizure frequency. Results: Among mTLE patients, we found functional network abnormalities throughout the limbic system, but primarily in the hemisphere ipsilateral to the seizure focus. The RSFCs between ipsilateral hypothalamus and ventral anterior cingulate cortex and between ipsilateral subiculum and contralateral posterior cingulate cortex were highly correlated with seizure frequency. Discussion: These findings suggest that in mTLE, changes in limbic networks ipsilateral to the epileptic focus are common. The pathological changes in connectivity between cingulate cortex, hypothalamus and subiculum ipsilateral to the seizure focus were correlated with increased seizure frequency. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Relationship between seizure frequency and functional abnormalities in limbic network of medial temporal lobe epilepsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Hang Joon | - |
dc.identifier.doi | 10.3389/fneur.2019.00488 | - |
dc.identifier.scopusid | 2-s2.0-85068085219 | - |
dc.identifier.wosid | 000467347100001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, v.10, pp.1 - 8 | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.citation.title | FRONTIERS IN NEUROLOGY | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | GRAPH-THEORY FINDINGS | - |
dc.subject.keywordPlus | HIPPOCAMPAL ATROPHY | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordAuthor | medial temporal lobe epilepsy | - |
dc.subject.keywordAuthor | partial seizure | - |
dc.subject.keywordAuthor | functional magnetic resonance imaging | - |
dc.subject.keywordAuthor | network-based statistics | - |
dc.subject.keywordAuthor | limbic system | - |
dc.identifier.url | https://www.frontiersin.org/articles/10.3389/fneur.2019.00488/full | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.