Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation
DC Field | Value | Language |
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dc.contributor.author | Hyun Jeong Je | - |
dc.contributor.author | Yoo Kyung Han | - |
dc.contributor.author | Hyeon Gyu Lee | - |
dc.contributor.author | In Young Bae | - |
dc.date.accessioned | 2022-07-10T01:08:01Z | - |
dc.date.available | 2022-07-10T01:08:01Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1976-0442 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148173 | - |
dc.description.abstract | The objectives of this study were to evaluate the antiaging effects and investigate the effect of simulated gastrointestinal (GI) digestion on the anti-aging properties and intestinal permeation of the potential fish collagen hydrolysates (FCH). Therefore, procollagen synthesis, matrix metalloproteinase-1 (MMP-1) production, and Caco-2 cell permeability were analyzed before and after in vitro digestion for FCHs, low-molecular weight fractions (<1 kDa), and high molecular weight fractions (>1 kDa). After being subjected to GI digestion, the level of MMP-1 inhibition was maintained, although the procollagen production was significantly (>20%) lower with all samples. Also, the digested FCHs and their <1 kDa fraction yielded 9.1 and 13.8% increased peptide transport, respectively, compared to undigested samples. Based on the effective intestinal permeation and high digestive enzyme stability, the <1 kDa fraction of FCHs is a potential bioactive material suitable for anti-aging applications in the food and cosmetics industries. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Korean Society for Applied Biological Chemistry | - |
dc.title | Anti-aging potential of fish collagen hydrolysates subjected to simulated gastrointestinal digestion and Caco-2 cell permeation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Hyeon Gyu Lee | - |
dc.identifier.doi | 10.3839/jabc.2019.015 | - |
dc.identifier.scopusid | 2-s2.0-85064338663 | - |
dc.identifier.bibliographicCitation | Journal of Applied Biological Chemistry, v.62, no.1, pp.101 - 107 | - |
dc.relation.isPartOf | Journal of Applied Biological Chemistry | - |
dc.citation.title | Journal of Applied Biological Chemistry | - |
dc.citation.volume | 62 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 107 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002446640 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Anti-aging peptide | - |
dc.subject.keywordAuthor | Cellular permeability | - |
dc.subject.keywordAuthor | Collagen synthesis Fish collagen hydrolysate | - |
dc.subject.keywordAuthor | Matrix metalloproteinase-1 inhibition | - |
dc.identifier.url | https://www.jabc.or.kr/journal/view.html?doi=10.3839/jabc.2019.015 | - |
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