The stability and oncogenic function of LIN28A are regulated by USP28
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Haq, Saba | - |
dc.contributor.author | Das, Soumyadip | - |
dc.contributor.author | Kim, Dong-Ho | - |
dc.contributor.author | Chandrasekaran, Arun Pandian | - |
dc.contributor.author | Hong, Seok-Ho | - |
dc.contributor.author | Kim, Kye-Seong | - |
dc.contributor.author | Ramakrishna, Suresh | - |
dc.date.accessioned | 2022-07-10T01:09:34Z | - |
dc.date.available | 2022-07-10T01:09:34Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0925-4439 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148195 | - |
dc.description.abstract | RNA-binding protein LIN28A is often highly expressed in human malignant tumors and is involved in tumor metastasis and poor prognosis. Knowledge about post-translational regulatory mechanisms governing LIN28A protein stability and function is scarce. Here, we investigated the role of ubiquitination and deubiquitination on LIN28A protein stability and report that LIN28A protein undergoes ubiquitination. Ubiquitin-specific protease 28 (USP28), a deubiquitinating enzyme, interacts with and stabilizes LIN28A protein to extend its half-life. USP28, through its deubiquitinating activity, antagonizes LIN28A protein turnover by reversing its proteasomal degradation. Our study describes the consequential impacts of USP28-mediated stabilization of LIN28A protein on enhancing cancer cell viability, migration and ultimately augmenting LIN28A-mediated tumor progression. Overall, our data suggest that a synergistic, combinatorial approach of targeting LIN28A with USP28 would contribute to effective cancer therapeutics. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | The stability and oncogenic function of LIN28A are regulated by USP28 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kye-Seong | - |
dc.contributor.affiliatedAuthor | Ramakrishna, Suresh | - |
dc.identifier.doi | 10.1016/j.bbadis.2018.12.006 | - |
dc.identifier.scopusid | 2-s2.0-85059327002 | - |
dc.identifier.wosid | 000458590600006 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v.1865, no.3, pp.599 - 610 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | - |
dc.citation.volume | 1865 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 599 | - |
dc.citation.endPage | 610 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | LET-7 MICRORNA BIOGENESIS | - |
dc.subject.keywordPlus | DEUBIQUITINATING ENZYME USP28 | - |
dc.subject.keywordPlus | HUMAN-CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | LIN-28 | - |
dc.subject.keywordAuthor | Cell viability | - |
dc.subject.keywordAuthor | CRISPR/Cas9 | - |
dc.subject.keywordAuthor | Knockout cell lines | - |
dc.subject.keywordAuthor | Let-7 | - |
dc.subject.keywordAuthor | Protein degradation | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925443918304927?via%3Dihub | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.