Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in ALK-positive lung cancer: Comparison with EGFR-mutated lung cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Kwon, Mi Jung | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Kim, Jeong Won | - |
dc.contributor.author | Hong, Mineui | - |
dc.contributor.author | Park, Hye-Rim | - |
dc.contributor.author | Min, Soo Kee | - |
dc.contributor.author | Choe, Ji-Young | - |
dc.contributor.author | Ra, Yong Joon | - |
dc.contributor.author | Jang, Seung Hun | - |
dc.contributor.author | Hwang, Yong Il | - |
dc.contributor.author | Kim, Ho Young | - |
dc.contributor.author | Min, Kyueng-Whan | - |
dc.date.accessioned | 2022-07-10T01:32:28Z | - |
dc.date.available | 2022-07-10T01:32:28Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148208 | - |
dc.description.abstract | ALK-positive (ALK+) lung adenocarcinoma usually shows a more advanced-staged disease with frequent nodal metastasis and highly aggressive outcomes compared with EGFR-mutated lung cancers. The aim of this study was to investigate the expression profiles of several mucins in ALK + lung cancers to gain insight into the relationship between the more aggressive biological nature of ALK + lung cancers and the role of mucins. We examined the immunohistochemical profiles of mucins MUC1, MUC2, MUC5AC, and MUC6 in 19 ALK + lung cancers compared with 42 EGFR-mutated lung cancers. ALK + cancers were found to occur in younger patients and were characterized by a solid-predominant histologic subtype with frequent signet ring cells and peritumoral muciphages. By contrast, EGFR-mutated cancers lacked ALK-specific histological patterns. Although all MUC1 and MUC5AC were expressed in both subtypes, MUC1 expression in ALK + cancers was visualized exclusively through cytoplasmic staining, whereas those in EGFR-mutated cancers were predominantly membranous staining in apical area (92.9%) and focally in cytoplasmic staining (7.1%). MUC5AC expression in ALK + cancers was exclusively visualized through cytoplasmic staining (100%), whereas EGFR-mutated cancers showed predominantly perinuclear dot-like patterns (90.5%) and focal cytoplasmic staining (9.5%). MUC2 and MUC6 expression was not detected in either type of lung cancer. Conclusions The high frequency of both MUC1 and MUC5AC cytoplasmic expression, coupled with a lack of MUC2 and MUC6 expression in ALK + lung cancer may contribute to the biologically aggressive behavior of ALK + cancer. Inhibitors to these types of mucins may thus act as a barrier to cancerous extension reducing their aggressive behavior. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER GMBH | - |
dc.title | Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in ALK-positive lung cancer: Comparison with EGFR-mutated lung cancer | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1016/j.prp.2018.12.011 | - |
dc.identifier.scopusid | 2-s2.0-85058629201 | - |
dc.identifier.wosid | 000460999500009 | - |
dc.identifier.bibliographicCitation | PATHOLOGY RESEARCH AND PRACTICE, v.215, no.3, pp 459 - 465 | - |
dc.citation.title | PATHOLOGY RESEARCH AND PRACTICE | - |
dc.citation.volume | 215 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 459 | - |
dc.citation.endPage | 465 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | KRAS | - |
dc.subject.keywordPlus | REARRANGEMENT | - |
dc.subject.keywordPlus | COEXPRESSION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Anaplastic lymphoma kinase | - |
dc.subject.keywordAuthor | Mucin | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Immunohistochemistry | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0344033818312305?via%3Dihub | - |
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