Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rahane, Chinmay Satish | - |
dc.contributor.author | Kutzner, Arne | - |
dc.contributor.author | Heese, Klaus | - |
dc.date.accessioned | 2022-07-10T14:55:41Z | - |
dc.date.available | 2022-07-10T14:55:41Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 2210-7762 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148520 | - |
dc.description.abstract | Adrenocortical carcinoma (ACC) is a rare and aggressive tumor whose molecular signaling pathways are not fully understood. Using an in-silico clinical data analysis approach we retrieved human gene mutation data from the highly reputed Cancer Genome Atlas (TCGA). ACC-specific gene mutations were correlated with proliferation marker FAM72 expression and Mutsig along with the algorithmic implementation of the 20/20 rule were used to validate their oncogenic potential. The newly identified oncogenic driver gene set (ZFPM1, LRIG1, CRIPAK, ZNF517, GARS and DGKZ), specifically and most repeatedly mutated in ACC, is involved in tumor suppression and cellular proliferation and thus could be useful for the prognosis and development of therapeutic approaches for the treatment of ACC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Establishing a human adrenocortical carcinoma (ACC)-specific gene mutation signature | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kutzner, Arne | - |
dc.contributor.affiliatedAuthor | Heese, Klaus | - |
dc.identifier.doi | 10.1016/j.cancergen.2018.10.005 | - |
dc.identifier.scopusid | 2-s2.0-85056991066 | - |
dc.identifier.wosid | 000472238800001 | - |
dc.identifier.bibliographicCitation | CANCER GENETICS, v.230, pp.1 - 12 | - |
dc.relation.isPartOf | CANCER GENETICS | - |
dc.citation.title | CANCER GENETICS | - |
dc.citation.volume | 230 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 12 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | GENOMIC CHARACTERIZATION | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LRIG1 | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | KINASES | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | Adrenal gland | - |
dc.subject.keywordAuthor | CRIPAK | - |
dc.subject.keywordAuthor | DGKZ | - |
dc.subject.keywordAuthor | LRIG1 | - |
dc.subject.keywordAuthor | Oncogene | - |
dc.subject.keywordAuthor | ZFPM1 | - |
dc.subject.keywordAuthor | Zinc finger | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S2210776218303661 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.