Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors
DC Field | Value | Language |
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dc.contributor.author | Ko, Seung Yeon | - |
dc.contributor.author | Wang, Sung Eun | - |
dc.contributor.author | Lee, Han Kyu | - |
dc.contributor.author | Jo, Sungsin | - |
dc.contributor.author | Han, Jinil | - |
dc.contributor.author | Lee, Seung Hoon | - |
dc.contributor.author | Choi, Miyeon | - |
dc.contributor.author | Jo, Hye-Ryeong | - |
dc.contributor.author | Seo, Jee Young | - |
dc.contributor.author | Jung, Sung Jun | - |
dc.contributor.author | Son, Hyeon | - |
dc.date.accessioned | 2022-07-10T14:57:30Z | - |
dc.date.available | 2022-07-10T14:57:30Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148559 | - |
dc.description.abstract | Major depressive disorder (MDD) is a devastating disease that arises in a background of environmental risk factors, such as chronic stress, that produce reactive oxygen species (ROS) in the brain. The chronic stress-induced ROS production involves Ca2+ signals; however, the mechanism is poorly understood. Transient receptor potential melastatin type 2 (TRPM2) is a Ca2+-permeable cation channel that is highly expressed in the brain. Here we show that in animal models of chronic unpredictable stress (CUS), deletion of TRPM2 (Trpm2(-/-)) produces antidepressant-like behaviors in mice. This phenotype correlates with reduced ROS, ROS-induced calpain activation, and enhanced phosphorylation of two Cdk5 targets including synapsin 1 and histone deacetylase 5 that are linked to synaptic function and gene expression, respectively. Moreover, TRPM2 mRNA expression is increased in hippocampal tissue samples from patients with MDD. Our findings suggest that TRPM2 is a key agent in stress-induced depression and a possible target for treating depression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Sung Jun | - |
dc.contributor.affiliatedAuthor | Son, Hyeon | - |
dc.identifier.doi | 10.1073/pnas.1814335116 | - |
dc.identifier.scopusid | 2-s2.0-85060809900 | - |
dc.identifier.wosid | 000456944600049 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.116, no.5, pp.1770 - 1775 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 116 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1770 | - |
dc.citation.endPage | 1775 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HIPPOCAMPAL NEUROGENESIS | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | MAJOR DEPRESSION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | TRPM2 | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | P35 | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordAuthor | TRPM2 | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordAuthor | Cdk5 | - |
dc.subject.keywordAuthor | neurogenesis | - |
dc.identifier.url | https://www.pnas.org/content/116/5/1770 | - |
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