Results of re-irradiation for pelvic recurrence in anorectal cancer patients
DC Field | Value | Language |
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dc.contributor.author | Park, Younghee | - |
dc.contributor.author | Kim, Kyubo | - |
dc.contributor.author | Park, Hae Jin | - |
dc.contributor.author | Jeong, Seung-Yong | - |
dc.contributor.author | Park, Kyu Joo | - |
dc.contributor.author | Han, Sae-Won | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.date.accessioned | 2022-07-10T15:01:38Z | - |
dc.date.available | 2022-07-10T15:01:38Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0007-1285 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148660 | - |
dc.description.abstract | Objective: To evaluate outcomes and toxicity profiles after re-irradiation in patients with pelvic recurrence of anorectal cancer. Methods: 25 anorectal cancer patients who received re-irradiation for pelvic recurrence between 2005 and 2015 were included. For initial treatment, all patients underwent surgical resection and preoperative or postoperative radiotherapy. Results: The median follow-up duration was 21.5 months (range, 2.9-84.4). After a median of 43.3 months (range, 11.7-218.5), patients received re-irradiation with a median dose of 45Gy (range, 36-60). The equivalent dose in 2Gy fractions (EQD2) of re-irradiation-calculated using alpha/beta = 10Gy-ranged from 34.5 to 84.0 Gy (median, 46.4). Surgical resection was performed for 11 patients, and 14 patients received concurrent chemotherapy with re-irradiation. The 3-year local progression-free survival was 29.7%. The 3-year overall survival was 49.7%. Concurrent chemotherapy with re-irradiation and re-irradiation doses >5OGy EQD2(alpha/beta=10) were significant prognostic factors for local progression free survival and overall survival according to multivariate analysis. 90% (9 of 10) of patients with symptoms had improvement after re-irradiation. Among 23 patients available for evaluation of late toxicity, 12 developed late toxicities. There were no Grade 4 late toxicities, and 6 patients had Grade 3 late toxicities (small bowel obstruction, bowel perforation and fistula). Conclusion: Re-irradiation for pelvic recurrence of anorectal cancer improved symptoms of patients but the rate of late toxicity was high. Further investigation for patient selection is required. Advances in knowledge: Re-irradiation could be considered as a possible option for pelvic recurrence of anorectal cancer in selected patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | BRITISH INST RADIOLOGY | - |
dc.title | Results of re-irradiation for pelvic recurrence in anorectal cancer patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hae Jin | - |
dc.identifier.doi | 10.1259/bjr.20180794 | - |
dc.identifier.scopusid | 2-s2.0-85064999851 | - |
dc.identifier.wosid | 000465204300008 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF RADIOLOGY, v.92, no.1097, pp.1 - 8 | - |
dc.relation.isPartOf | BRITISH JOURNAL OF RADIOLOGY | - |
dc.citation.title | BRITISH JOURNAL OF RADIOLOGY | - |
dc.citation.volume | 92 | - |
dc.citation.number | 1097 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | RECTAL-CANCER | - |
dc.subject.keywordPlus | LOCALLY RECURRENT | - |
dc.subject.keywordPlus | PREOPERATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | SURGERY | - |
dc.identifier.url | https://www.birpublications.org/doi/10.1259/bjr.20180794 | - |
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