Continuous-mode separation of fucose and 2,3-butanediol using a three-zone simulated moving bed process and its performance improvement by using partial extract-collection, partial extract-recycle, and partial desorbent-port closing
DC Field | Value | Language |
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dc.contributor.author | Lee, Chung-Gi | - |
dc.contributor.author | Jo, Cheol Yeon | - |
dc.contributor.author | Song, Ye Jin | - |
dc.contributor.author | Mun, Sungyong | - |
dc.date.accessioned | 2022-07-10T21:03:06Z | - |
dc.date.available | 2022-07-10T21:03:06Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0021-9673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148887 | - |
dc.description.abstract | If a multi-component monosugar mixture including fucose was used as the substrates for the Klebsiella oxytoca fermentation, it could offer the following two benefits simultaneously; (i) the removal of all monosugars other than fucose, and (ii) the acquisition of 2,3-butanediol (BD). To utilize such two benefits in favor of the economical efficiency of the fucose production process, it is essential to accomplish a high purity separation between fucose and BD on the basis of a highly -economical mode. To address this issue, we aimed to develop a simulated moving bed (SMB) process for continuous-mode separation of fucose and BD with high purities. It was first found that an Amberchrom-CG71C resin could become a suitable adsorbent for the separation of interest. The intrinsic parameters of fucose and BD on such proven adsorbent were determined, and then applied to the optimal design of the fucose-BD separation SMB. The capability of the designed SMB in ensuring high purities and high yields was experimentally verified. Finally, we devised two potential strategies to make a further improvement in product concentrations and/or desorbent usage while keeping the purities and yields of fucose and BD almost unchanged. The first strategy was based on partial extract-collection and partial extract-discard, which was found to result in 33% higher BD product concentration. The second strategy was based on partial extract-collection, partial extract-recycle, and partial desorbent-port closing, which could lead to 25% lower desorbent usage, 33% higher BD product concentration, and 7% higher fucose product concentration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Continuous-mode separation of fucose and 2,3-butanediol using a three-zone simulated moving bed process and its performance improvement by using partial extract-collection, partial extract-recycle, and partial desorbent-port closing | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Mun, Sungyong | - |
dc.identifier.doi | 10.1016/j.chroma.2018.10.029 | - |
dc.identifier.scopusid | 2-s2.0-85055676688 | - |
dc.identifier.wosid | 000452343700006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHROMATOGRAPHY A, v.1579, pp.49 - 59 | - |
dc.relation.isPartOf | JOURNAL OF CHROMATOGRAPHY A | - |
dc.citation.title | JOURNAL OF CHROMATOGRAPHY A | - |
dc.citation.volume | 1579 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 59 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.subject.keywordPlus | STANDING-WAVE DESIGN | - |
dc.subject.keywordPlus | MULTIOBJECTIVE OPTIMIZATION | - |
dc.subject.keywordPlus | SMB | - |
dc.subject.keywordPlus | CHROMATOGRAPHY | - |
dc.subject.keywordPlus | OPERATION | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | STRATEGY | - |
dc.subject.keywordPlus | SUGARS | - |
dc.subject.keywordPlus | FLOW | - |
dc.subject.keywordAuthor | Simulated moving bed | - |
dc.subject.keywordAuthor | Fucose | - |
dc.subject.keywordAuthor | 2,3-butanediol | - |
dc.subject.keywordAuthor | Continuous separation | - |
dc.subject.keywordAuthor | Operation strategies | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0021967318312925?via%3Dihub | - |
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