Thickness of retina and choroid in the elderly population and its association with Complement Factor H polymorphism: KLoSHA Eye study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryoo, Na-Kyung | - |
dc.contributor.author | Ahn, Seong Joon | - |
dc.contributor.author | Park, Kyu Hyung | - |
dc.contributor.author | Ahn, Jeeyun | - |
dc.contributor.author | Seo, Jiyeong | - |
dc.contributor.author | Han, Ji Won | - |
dc.contributor.author | Kim, Ki Woong | - |
dc.contributor.author | Woo, Se Joon | - |
dc.date.accessioned | 2022-07-10T22:51:35Z | - |
dc.date.available | 2022-07-10T22:51:35Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148910 | - |
dc.description.abstract | Purpose To analyze the associations of retinal and choroidal thickness on enhanced-depth imaging optical coherence tomography (EDI-OCT) with clinical, ophthalmic and genetic factors in the normal elderly population (aged 65 years or older). Methods In this prospective, population-based cohort study, people aged 65 years or older were enrolled in the baseline study of the Korean Longitudinal Study on Health and Aging (KLoSHA) Eye Study. All participants underwent spectral domain-OCT scan using the EDI technique. A topographic map of the retina was obtained and subfoveal choroidal thickness (SFCT) was measured manually. Blood samples from all subjects were genotyped for major age-related macular degeneration (AMD)-associated single nucleotide polymorphisms (SNPs) the major AMD-associated SNPs; CFH Y402H rs1061170, CFH I62V rs800292, ARMS2 A69S rs10490924. A statistical analysis was conducted to compare the retinal thickness, choroidal thickness, and AMD risk genotypes. Results Among the three hundred eighty people enrolled, the mean age was 76.6 years (range 65–99 years). Factors that showed correlation with either tomographic retinal parameters, retinal nerve fiber layer, or SFCT, were age and gender. Significant age-related decrease in thickness was observed in the RNFL, mean central thickness (MCT) and SFCT. Gender differences existed in central foveolar thickness (CFT) and MCT, where it was thicker in men. While chorioretinal parameters were not related with other genotypes, CFH rs1061170 risk genotype was significantly associated with thin SFCT. The group containing the AMD- risk allele (CT) had a 14.7% reduction in the SFCT compared to the non-risk TT group. Conclusions In addition to the well-known association with AMD, CFH rs1061170 is a significant genetic risk factor associated with choroidal thinning in normal eyes of the elderly population. Such findings may provide further insight into the pathogenesis of age-related macular degeneration as well as normal aging. In addition, our study provides the first normative data on retinal and choroidal thickness in population-based aged groups with a mean age over seventy-five. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Thickness of retina and choroid in the elderly population and its association with Complement Factor H polymorphism: KLoSHA Eye study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Seong Joon | - |
dc.identifier.doi | 10.1371/journal.pone.0209276 | - |
dc.identifier.scopusid | 2-s2.0-85059284910 | - |
dc.identifier.wosid | 000454627200039 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.13, no.12, pp.1 - 15 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 15 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NERVE-FIBER LAYER | - |
dc.subject.keywordPlus | OPTICAL COHERENCE TOMOGRAPHY | - |
dc.subject.keywordPlus | MACULAR-DEGENERATION | - |
dc.subject.keywordPlus | VASCULAR HYPERPERMEABILITY | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | CHORIOCAPILLARIS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | ETHNICITY | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | OCT | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209276 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.