Loss of Wnt7a expression correlates with tumor progression and poor prognosis in colorectal carcinoma
- Authors
- Jang, Se Min; Wi, Young Chan; Kim, Yeseul; Bang, Seong Sik; Sim, Jongmin; Ahn, Byung kyu; Lee, Kang Hong; Shin, Jin; Jang, Kiseok; Paik, Seung Sam
- Issue Date
- Oct-2018
- Publisher
- e-Century Publishing Corporation
- Keywords
- Wnt7a; carcinogenesis; prognosis; colorectum; adenocarcinoma
- Citation
- International Journal of Clinical and Experimental Pathology, v.11, no.10, pp.4967 - 4976
- Indexed
- SCIE
- Journal Title
- International Journal of Clinical and Experimental Pathology
- Volume
- 11
- Number
- 10
- Start Page
- 4967
- End Page
- 4976
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149217
- ISSN
- 1936-2625
- Abstract
- Wnt7a is a known tumor suppressor gene in non-small cell lung cancer that regulates normal cellular proliferation and differentiation. The purpose of this study was to investigate the clinicopathologic significance of Wnt7a expression in colorectal adenocarcinoma. Wnt7a expression was immunohistochemically examined in 46 normal colorectal tissues, 47 tubular adenomas, 393 adenocarcinomas, and 93 lymph node metastases. Wnt7a was expressed in the cytoplasm. Loss of Wnt7a expression was more frequent in adenocarcinoma and lymph node metastasis compared to that in normal and tubular adenoma (P < 0.001). Wnt7a expression was inversely correlated with tumor size (P = 0.026), gross type (P = 0.008), differentiation (P = 0.009), vascular invasion (P = 0.038), tumor deposit (P = 0.007), tumor invasion (T category) (P = 0.003), lymph node metastasis (N category) (P < 0.001), and AJCC stage (P < 0.001). There was a significant correlation between loss of Wnt7a expression and overall survival and disease-free survival (P < 0.001 and P = 0.001, respectively) on univariable analysis. On multivariable analysis, loss of Wnt7a expression was an independent prognostic factor for both overall and disease-free survival (P = 0.002 and P = 0.047, respectively). Loss of Wnt7a expression may contribute to the carcinogenesis and tumor progression of colorectal adenocarcinoma and may be a new prognostic marker of colorectal adenocarcinoma.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 병리학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 외과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149217)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.