Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM
DC Field | Value | Language |
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dc.contributor.author | Park, Min Hee | - |
dc.contributor.author | Lee, Ju Youn | - |
dc.contributor.author | Park, Kang Ho | - |
dc.contributor.author | Jung, In Kyung | - |
dc.contributor.author | Kim, Kyoung-Tae | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Ryu, Hyun-Hee | - |
dc.contributor.author | Jeong, Yong | - |
dc.contributor.author | Kang, Minseok | - |
dc.contributor.author | Schwaninger, Markus | - |
dc.contributor.author | Gulbins, Erich | - |
dc.contributor.author | Reichel, Martin | - |
dc.contributor.author | Kornhuber, Johannes | - |
dc.contributor.author | Yamaguchi, Tomoyuki | - |
dc.contributor.author | Kim, Hee Jin | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.contributor.author | Schuchman, Edward H. | - |
dc.contributor.author | Jin, Hee Kyung | - |
dc.contributor.author | Bae, Jae-Sung | - |
dc.date.accessioned | 2022-07-11T08:15:15Z | - |
dc.date.available | 2022-07-11T08:15:15Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149284 | - |
dc.description.abstract | Although many reports have revealed dysfunction of endothelial cells in aging, resulting in blood-brain barrier (BBB) breakdown, the underlying mechanism or mechanisms remain to be explored. Here, we find that acid sphingomyelinase (ASM) is a critical factor for regulating brain endothelial barrier integrity. ASM is increased in brain endothelium and/or plasma of aged humans and aged mice, leading to BBB disruption by increasing caveolae-mediated transcytosis. Genetic inhibition and endothelial-specific knockdown of ASM in mice ameliorated BBB breakdown and neurocognitive impairment during aging. Using primary mouse brain endothelial cells, we found that ASM regulated the caveolae-cytoskeleton interaction through protein phosphatase 1-mediated ezrin/radixin/moesin (ERM) dephosphorylation and apoptosis. Moreover, mice with conditional ASM overexpression in brain endothelium accelerated significant BBB impairment and neurodegenerative change. Overall, these results reveal a novel role for ASM in the control of neurovascular function in aging, suggesting that ASM may represent a new therapeutic target for anti-aging. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hee Jin | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.identifier.doi | 10.1016/j.neuron.2018.09.010 | - |
dc.identifier.scopusid | 2-s2.0-85054143700 | - |
dc.identifier.wosid | 000446862000018 | - |
dc.identifier.bibliographicCitation | NEURON, v.100, no.1, pp.167 - 182 | - |
dc.relation.isPartOf | NEURON | - |
dc.citation.title | NEURON | - |
dc.citation.volume | 100 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 167 | - |
dc.citation.endPage | 182 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | ACID SPHINGOMYELINASE/CERAMIDE PATHWAY | - |
dc.subject.keywordPlus | CAVEOLAE-MEDIATED TRANSCYTOSIS | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CYTOSKELETON | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | acid sphingomyelinase | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | blood-brain barrier | - |
dc.subject.keywordAuthor | caveolae | - |
dc.subject.keywordAuthor | neural function | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0896627318307839?via%3Dihub | - |
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