Preparation of antibacterial TiO₂ particles by hybridization with azelaic acid for applications in cosmetics

Abstract

To apply as the antimicrobial agent in cosmetics, azelaic acid, a skin lightening material with anti-inflammatory and antimicrobial properties, has been employed to functionalize TiO2 microspheres. Prior to the functionalization process, TiO2 microspheres were modified with NaOH to introduce hydroxyl groups on the surface of TiO2 as chemical binders. Hybridization was performed by condensation reaction between hydroxyl groups introduced on the surface of TiO2 by hydroxylation process and the hydroxyl groups of azelaic acid. The azelaic acid-TiO2 composites showed high antimicrobial activities towards both gram positive and gram negative bacterial strains, which are Staphylococcus aureus and Escherichia coll.