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A pilot study of GABA(B) correlates with resting-state functional connectivity in five depressed female adolescentsopen access
- Authors
- Balzekas, Irena; Lewis, Charles P.; Shekunov, Julia; Port, John D.; Worrell, Gregory A.; Jo, Hang Joon; Croarkin, Paul E.
- Issue Date
- Sep-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- TMS, fMRI; Connectivity; Resting state; Depression
- Citation
- PSYCHIATRY RESEARCH-NEUROIMAGING, v.279, pp.60 - 63
- Indexed
- SCIE
SCOPUS
- Journal Title
- PSYCHIATRY RESEARCH-NEUROIMAGING
- Volume
- 279
- Start Page
- 60
- End Page
- 63
- ISSN
- 0925-4927
- Abstract
- Connectivity features based on resting-state (RS) functional magnetic resonance imaging (fMRI) demonstrate great promise as biomarkers to guide diagnosis and treatment in major depressive disorder (MDD). However, there is a pressing need for valid, reliable biomarkers closer to the bedside for clinical research and practice. This study directly compared RS-fMRI connectivity features with transcranial magnetic stimulation (TMS) neurophysiological measures, long interval cortical inhibition (LICI) and cortical silent period (CSP), in female adolescents with MDD. LICI-200 showed the most significant associations with RS functional connectivity features, demonstrating its potential to evaluate the neurochemical underpinnings of network features in MDD.
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Related Researcher
- Jo, Hang Joon
- COLLEGE OF MEDICINE (DEPARTMENT OF PHYSIOLOGY)