Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis
DC Field | Value | Language |
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dc.contributor.author | Oh, Ki-Wook | - |
dc.contributor.author | Noh, Min-Young | - |
dc.contributor.author | Kwon, Min-Soo | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Oh, Seong-il | - |
dc.contributor.author | Park, Jinseok | - |
dc.contributor.author | Kim, Hee-Jin | - |
dc.contributor.author | Ki, Chang-Seok | - |
dc.contributor.author | Kim, Seung Hyun | - |
dc.date.accessioned | 2022-07-11T09:33:58Z | - |
dc.date.available | 2022-07-11T09:33:58Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 0364-5134 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149393 | - |
dc.description.abstract | ObjectiveTo assess the safety and efficacy of 2 repeated intrathecal injections of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) in amyotrophic lateral sclerosis (ALS). MethodsIn a phase 2 randomized controlled trial (NCT01363401), 64 participants with ALS were randomly assigned treatments (1:1) of riluzole alone (control group, n = 31) or combined with 2 BM-MSC injections (MSC group, n = 33). Safety was assessed based on the occurrence of adverse events. The primary efficacy outcome was changes in Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score from baseline to 4 and 6 months postinjection. Post hoc analysis includes investigation of cerebrospinal fluid biomarkers and long-term survival analysis. ResultsSafety rating showed no groupwise difference with absence of serious treatment-related adverse events. Mean changes in ALSFRS-R scores from baseline to 4 and 6 months postinjection were reduced in the MSC group compared with the control group (4 months: 2.98, 95% confidence interval [CI] = 1.48-4.47, p < 0.001; 6 months: 3.38, 95% CI = 1.23-5.54, p = 0.003). The MSC group showed decreased proinflammatory and increased anti-inflammatory cytokines. In good responders, transforming growth factor 1 significantly showed inverse correlation with monocyte chemoattractant protein-1. There was no significant difference in long-term survival between groups. InterpretationRepeated intrathecal injections of BM-MSCs demonstrated a possible clinical benefit lasting at least 6 months, with safety, in ALS patients. A plausible action mechanism is that BM-MSCs mediate switching from pro- to anti-inflammatory conditions. A future randomized, double-blind, large-scale phase 3 clinical trial with additional BM-MSC treatments is required to evaluate long-term efficacy and safety. Ann Neurol 2018;84:361-373 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Ki-Wook | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Young | - |
dc.contributor.affiliatedAuthor | Park, Jinseok | - |
dc.contributor.affiliatedAuthor | Kim, Hee-Jin | - |
dc.contributor.affiliatedAuthor | Kim, Seung Hyun | - |
dc.identifier.doi | 10.1002/ana.25302 | - |
dc.identifier.scopusid | 2-s2.0-85052821268 | - |
dc.identifier.wosid | 000445328100003 | - |
dc.identifier.bibliographicCitation | ANNALS OF NEUROLOGY, v.84, no.3, pp.361 - 373 | - |
dc.relation.isPartOf | ANNALS OF NEUROLOGY | - |
dc.citation.title | ANNALS OF NEUROLOGY | - |
dc.citation.volume | 84 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 361 | - |
dc.citation.endPage | 373 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | ALS | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/ana.25302 | - |
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