Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander-Implant Breast Reconstruction After Postmastectomy Radiotherapy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Il-Kug | - |
dc.contributor.author | Park, Seong Oh | - |
dc.contributor.author | Chang, Hak | - |
dc.contributor.author | Jin, Ung Sik | - |
dc.date.accessioned | 2022-07-11T13:24:32Z | - |
dc.date.available | 2022-07-11T13:24:32Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149577 | - |
dc.description.abstract | Background Capsular contracture is one of the most common complications of expander–implant breast reconstruction. Recently, clinical reports have shown that use of an acellular dermal matrix (ADM) to cover breast implants decreases incidence of capsular contracture, but the underlying mechanism is unclear. Here, we examine how ADM reduces capsular formation in expander–implant breast reconstruction and identify cellular and molecular mechanisms of ADM-mediated reduction of capsular contracture in nonirradiated and irradiated patients. Methods Thirty patients who underwent immediate two-stage implant-based breast reconstruction were included; 15 received radiotherapy. While the tissue expander was changed to permanent silicone implant, biopsies of the subpectoral capsule and ADM capsule were performed. Capsule thickness, immunohistochemistry of α-smooth muscle actin (αSMA), vimentin, CD31, F4/80 expression, αSMA and CD31 coexpression, and relative gene expression levels of transforming growth factor (TGF)-β1 and platelet-derived growth factor (PDGF)-B were investigated. Results Irradiated submuscular capsules were thicker than nonirradiated submuscular capsules, but the thickness of ADM capsules did not significantly differ between nonirradiated and irradiated groups. Levels of myofibroblasts, fibroblasts, vascularity, EndoMT, and macrophages were significantly lower in ADM capsules than in submuscular capsules. With the exception of EndoMT, all others were increased in irradiated submuscular capsules compared with nonirradiated submuscular capsule, while none significantly differed between nonirradiated and irradiated ADM capsules. Conclusions Use of ADM reduced myofibroblasts, vascularity, fibroblasts, and EndoMT in capsule tissues. Moreover, ADM use decreased macrophages, a key regulator of tissue fibrosis, as well as TGF-β1 and PDGF-B expression. We hope that these results provide basic concepts important for prevention of capsular contracture. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.title | Inhibition Mechanism of Acellular Dermal Matrix on Capsule Formation in Expander-Implant Breast Reconstruction After Postmastectomy Radiotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Seong Oh | - |
dc.identifier.doi | 10.1245/s10434-018-6549-8 | - |
dc.identifier.scopusid | 2-s2.0-85047946585 | - |
dc.identifier.wosid | 000437120000030 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, v.25, no.8, pp.2279 - 2287 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.title | ANNALS OF SURGICAL ONCOLOGY | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2279 | - |
dc.citation.endPage | 2287 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | TO-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | POSTOPERATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | PREMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | CANCER PATIENTS | - |
dc.subject.keywordPlus | CONTRACTURE | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | ALLODERM | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-018-6549-8 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.