U-Shaped Association Between Serum Uric Acid Level and Risk of Mortality: A Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung Kweon | - |
dc.contributor.author | Chang, Yoosoo | - |
dc.contributor.author | Kim, Inah | - |
dc.contributor.author | Ryu, Seungho | - |
dc.date.accessioned | 2022-07-11T15:49:57Z | - |
dc.date.available | 2022-07-11T15:49:57Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-07 | - |
dc.identifier.issn | 2326-5191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149736 | - |
dc.description.abstract | Objective. In addition to the controversy regarding the association of hyperuricemia with cardiovascular disease (CVD) mortality, few studies have examined the impact of a low uric acid level on mortality. We undertook the present study to evaluate the relationship between both low and high uric acid levels and the risk of all-cause and cause-specific mortality in a large sample of Korean adults over a full range of uric acid levels. Methods. A cohort study was performed in 375,163 South Korean men and women who underwent health check-ups from 2002 to 2012. Vital status and cause of death were ascertained from the national death records. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for mortality outcomes were estimated using Cox proportional hazards regression analysis. Results. During a total of 2,060,721.9 person-years of follow-up, 2,020 participants died, with 287 CVD deaths and 963 cancer deaths. Low and high uric acid levels were associated with increased all-cause, CVD, and cancer mortality. The multivariable-adjusted HRs for all-cause mortality in the lowest uric acid categories (<3.5 mg/dl for men and <2.5 mg/dl for women) compared with the sex-specific reference category were 1.58 (95% CI 1.18-2.10) and 1.80 (95% CI 1.10-2.93), respectively. Corresponding HRs in the highest uric acid categories (>= 9.5 mg/dl for men and >= 8.5 mg/dl for women) were 2.39 (95% CI 1.57-3.66) and 3.77 (95% CI 1.17-12.17), respectively. Conclusion. In this large cohort study of men and women, both low and high uric acid levels were predictive of increased mortality, supporting a U-shaped association between serum uric acid levels and adverse health outcomes. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | John Wiley and Sons Ltd | - |
dc.title | U-Shaped Association Between Serum Uric Acid Level and Risk of Mortality: A Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Inah | - |
dc.identifier.doi | 10.1002/art.40472 | - |
dc.identifier.scopusid | 2-s2.0-85047422074 | - |
dc.identifier.wosid | 000436236500018 | - |
dc.identifier.bibliographicCitation | Arthritis and Rheumatology, v.70, no.7, pp.1122 - 1132 | - |
dc.relation.isPartOf | Arthritis and Rheumatology | - |
dc.citation.title | Arthritis and Rheumatology | - |
dc.citation.volume | 70 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1122 | - |
dc.citation.endPage | 1132 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | ALL-CAUSE MORTALITY | - |
dc.subject.keywordPlus | CANCER-MORTALITY | - |
dc.subject.keywordPlus | CARDIOVASCULAR MORTALITY | - |
dc.subject.keywordPlus | ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | KIDNEY-FUNCTION | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | URATE | - |
dc.subject.keywordPlus | HYPOURICEMIA | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | DISEASE | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/art.40472 | - |
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