Wireless opto-electro neural interface for experiments with small freely behaving animalsopen access
- Authors
- Jia, Yaoyao; Khan, Wasif; Lee, Byung hun; Fan, Bin; Madi, Fatma; Weber, Arthur; Li, Wen; Ghovanloo, Maysam
- Issue Date
- Jun-2018
- Publisher
- IOP PUBLISHING LTD
- Keywords
- wireless opto-electro neural interface (WOENI); small freely behaving animals; ECoG recording; optical stimulation on V1; visual stimulation
- Citation
- JOURNAL OF NEURAL ENGINEERING, v.15, no.4, pp.1 - 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEURAL ENGINEERING
- Volume
- 15
- Number
- 4
- Start Page
- 1
- End Page
- 13
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149853
- DOI
- 10.1088/1741-2552/aac810
- ISSN
- 1741-2560
- Abstract
- Objective. We have developed a wireless opto-electro interface (WOENI) device, which combines electrocorticogram (ECoG) recording and optical stimulation for bi-directional neuromodulation on small, freely behaving animals, such as rodents. Approach. The device is comprised of two components, a detachable headstage and an implantable polyimide-based substrate. The headstage establishes a bluetooth low energy (BLE) bi-directional data communication with an external custom-designed USB dongle for receiving user commands and optogenetic stimulation patterns, and sending digitalized ECoG data. Main results. The functionality and stability of the device were evaluated in vivo on freely behaving rats. When the animal received optical stimulation on the primary visual cortex (V1) and visual stimulation via eyes, spontaneous changes in ECoG signals were recorded from both left and right V1 during four consecutive experiments with 7 d intervals over a time span of 21 d following device implantation. Immunostained tissue analyses showed results consistent with ECoG analyses, validating the efficacy of optical stimulation to upregulate the activity of cortical neurons expressing ChR2. Significance. The proposed WOENI device is potentially a versatile tool in the studies that involve long-term optogenetic neuromodulation.
- Files in This Item
-
Go to Link
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149853)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.