Identification of recurrence-associated microRNAs in stage I lung adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Sim, Jongmin | - |
dc.contributor.author | Kim, Yeseul | - |
dc.contributor.author | Kim, Hyunsung | - |
dc.contributor.author | Shin, Su-Jin | - |
dc.contributor.author | Kim, Dong-Hoon | - |
dc.contributor.author | Paik, Seung Sam | - |
dc.contributor.author | Jang, Kiseok | - |
dc.date.accessioned | 2022-07-11T17:26:23Z | - |
dc.date.available | 2022-07-11T17:26:23Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149953 | - |
dc.description.abstract | Lung cancer is the most common cause of cancer-associated death worldwide. Postoperative relapse and subsequent metastasis result in a high mortality rate, even in early stage lung cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level and are frequently dysregulated in various cancers. The aim of this study was to identify recurrence-associated miRNAs in early stage lung cancer. To screen for differentially expressed miRNAs related to postoperative recurrence, miRNA microarray data derived from stage I lung adenocarcinoma formalin-fixed paraffin-embedded (FFPE) tissue samples (n=6) and publically available the Cancer Genome Atlas (TCGA) data were analyzed. An independent sample (n=29) was used to validate candidate miRNAs by quantitative real-time polymerase chain reaction (qRT-PCR). In miRNA expression profiling, we identified 60 significantly dysregulated miRNAs in the relapsed group. Additionally, 20 dysregulated miRNAs were found using TCGA data set. Three miRNAs (let-7g-5p, miR-143-3p, and miR-374a-5p) were associated with postoperative recurrence in both microarray and TCGA data sets. All 3 candidate miRNAs were validated in the independent cohort of stage I adenocarcinoma by qRT-PCR. We discovered 3 recurrence-associated miRNAs of stage I lung adenocarcinoma samples using FFPE tissue, which showed possible clinical utility as biomarkers predicting recurrence after curative surgery. Further investigation of the functional properties of these miRNAs is needed. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Identification of recurrence-associated microRNAs in stage I lung adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Paik, Seung Sam | - |
dc.contributor.affiliatedAuthor | Jang, Kiseok | - |
dc.identifier.doi | 10.1097/MD.0000000000010996 | - |
dc.identifier.scopusid | 2-s2.0-85050133743 | - |
dc.identifier.wosid | 000439547300014 | - |
dc.identifier.bibliographicCitation | MEDICINE, v.97, no.25, pp.1 - 6 | - |
dc.relation.isPartOf | MEDICINE | - |
dc.citation.title | MEDICINE | - |
dc.citation.volume | 97 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | MIR-374A PROMOTES | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIR-143 | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | SAMPLES | - |
dc.subject.keywordPlus | LET-7G | - |
dc.subject.keywordPlus | OSTEOSARCOMA | - |
dc.subject.keywordAuthor | adenocarcinoma | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | stage | - |
dc.identifier.url | https://journals.lww.com/md-journal/Fulltext/2018/06220/Identification_of_recurrence_associated_microRNAs.14.aspx | - |
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