Effect of Starting Penile Rehabilitation with Sildenafil Immediately after Robot-Assisted Laparoscopic Radical Prostatectomy on Erectile Function Recovery: A Prospective Randomized Trial
DC Field | Value | Language |
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dc.contributor.author | Jo, Jung Ki | - |
dc.contributor.author | Jeong, Seong Jin | - |
dc.contributor.author | Oh, Jong Jin | - |
dc.contributor.author | Lee, Sang Wook | - |
dc.contributor.author | Lee, Sangchul | - |
dc.contributor.author | Hong, Sung Kyu | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Lee, Sang Eun | - |
dc.date.accessioned | 2022-07-11T17:26:30Z | - |
dc.date.available | 2022-07-11T17:26:30Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149954 | - |
dc.description.abstract | Purpose: It has not been clearly proved in real practice whether early rehabilitation with phosphodiesterase type 5 inhibitors starting immediately after radical prostatectomy improves erectile function recovery more effectively than delayed treatment with the same regimen. We performed a prospective randomized trial to identify this. Materials and Methods: Patients with prostate cancer and an IIEF-5 (International Index of Erectile Function-5) preoperative score of 17 or greater were randomly assigned to receive sildenafil 100 mg regularly twice per week for 3 months immediately after urethral catheter removal as the early group or only 3 months after nerve sparing robot-assisted laparoscopic radical prostatectomy as the delayed group. The study primary end point was the full erectile function recovery rate, defined as an IIEF-5 score of 17 or greater, during the 12 months. Results: Of the 120 randomized patients the proportion who achieved full recovery was significantly higher during the 12 months in the early group than in the delayed group (beta = 0.356, p <0.001, generalized estimating equation). After 9 months postoperatively the proportion of patients who achieved full recovery steadily increased to 41.4% at 12 months in the early group while patients in the delayed group showed no further improvement. Thus, full recovery was achieved in only 17.7% of patients at 12 months. Only early sildenafil treatment independently improved full recovery at 12 months (HR 2.943, p = 0.034). Conclusions: Our trial provides clinical data to suggest that earlier rehabilitation with phosphodiesterase type 5 inhibitors can contribute to the recovery of erectile function after radical prostatectomy in the clinical setting. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Effect of Starting Penile Rehabilitation with Sildenafil Immediately after Robot-Assisted Laparoscopic Radical Prostatectomy on Erectile Function Recovery: A Prospective Randomized Trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jo, Jung Ki | - |
dc.identifier.doi | 10.1016/j.juro.2017.12.060 | - |
dc.identifier.scopusid | 2-s2.0-85045712429 | - |
dc.identifier.wosid | 000431859900110 | - |
dc.identifier.bibliographicCitation | JOURNAL OF UROLOGY, v.199, no.6, pp.1601 - 1607 | - |
dc.relation.isPartOf | JOURNAL OF UROLOGY | - |
dc.citation.title | JOURNAL OF UROLOGY | - |
dc.citation.volume | 199 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1601 | - |
dc.citation.endPage | 1607 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | RETROPUBIC PROSTATECTOMY | - |
dc.subject.keywordPlus | MEN | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | VARDENAFIL | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | URINARY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | penis | - |
dc.subject.keywordAuthor | prostatectomy | - |
dc.subject.keywordAuthor | robotic surgical procedures | - |
dc.subject.keywordAuthor | erectile dysfunction | - |
dc.subject.keywordAuthor | phosphodiesterase 5 inhibitors | - |
dc.identifier.url | https://www.auajournals.org/doi/10.1016/j.juro.2017.12.060 | - |
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