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Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Tai Kyoung | - |
| dc.contributor.author | Kim, Joung Eun | - |
| dc.contributor.author | Youn, Ui Joung | - |
| dc.contributor.author | Han, Se Jong | - |
| dc.contributor.author | Kim, Il-Chan | - |
| dc.contributor.author | Cho, Cheon-Gyu | - |
| dc.contributor.author | Yim, Joung Han | - |
| dc.date.accessioned | 2022-07-11T17:26:46Z | - |
| dc.date.available | 2022-07-11T17:26:46Z | - |
| dc.date.created | 2021-05-12 | - |
| dc.date.issued | 2018-06 | - |
| dc.identifier.issn | 0163-3864 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149956 | - |
| dc.description.abstract | The first total syntheses of the natural products lobaric acid (1) and its derivatives isolated from the Antarctic lichen Stereocaulon alpinum are reported in this study. Lobarin (3), with a pseudodepsidone structure, was synthesized first in 11 steps by utilizing an Ullmann aryl ether coupling reaction, and lobaric acid was synthesized in an additional three steps by a seven-membered lactonization reaction. Various derivatives were also obtained from the prepared lobaric acid, and the synthetic compounds exhibited significant PTP1B inhibitory activities. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.title | Total Syntheses of Lobaric Acid and Its Derivatives from the Antarctic Lichen Stereocaulon alpinum | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Cho, Cheon-Gyu | - |
| dc.identifier.doi | 10.1021/acs.jnatprod.8b00227 | - |
| dc.identifier.scopusid | 2-s2.0-85049007180 | - |
| dc.identifier.wosid | 000436527100019 | - |
| dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.81, no.6, pp.1460 - 1467 | - |
| dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
| dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
| dc.citation.volume | 81 | - |
| dc.citation.number | 6 | - |
| dc.citation.startPage | 1460 | - |
| dc.citation.endPage | 1467 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Plant Sciences | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
| dc.subject.keywordPlus | DEPSIDONE SYNTHESIS | - |
| dc.subject.keywordPlus | ETHERS | - |
| dc.subject.keywordPlus | METABOLITES | - |
| dc.subject.keywordPlus | CELLS | - |
| dc.identifier.url | https://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00227 | - |
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Related Researcher
- Cho, Cheon Gyu
- COLLEGE OF NATURAL SCIENCES (DEPARTMENT OF CHEMISTRY)