Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells
DC Field | Value | Language |
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dc.contributor.author | Koh, Hani | - |
dc.contributor.author | Rah, Wee-Jin | - |
dc.contributor.author | Kim, Yong Joo | - |
dc.contributor.author | Moon, Jin Hwa | - |
dc.contributor.author | Kim, Mi Jung | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2022-07-11T22:09:36Z | - |
dc.date.available | 2022-07-11T22:09:36Z | - |
dc.date.created | 2021-05-13 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150073 | - |
dc.description.abstract | Background: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). Methods: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples. Results: There were no significant differences in cytokine levels between the mPBMC and placebo groups over 6 months. However, when clinical responders and non-responders were compared, interleukin (IL)-6 (P = 0.050) as well as G-CSF (P = 0.010) were higher in the responders than the non-responders at 1 month, while brain-derived neurotrophic factor (BDNF) (P = 0.030) and insulin-like growth factor (IGF)-1 (P = 0.001) were lower. In addition, BDNF was higher at baseline in the responders than the non-responders (P = 0.030). Conclusion: The changes of G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated with the clinical improvement of neurologic functions. The G-CSF- induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의학회 | - |
dc.title | Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong Joo | - |
dc.contributor.affiliatedAuthor | Moon, Jin Hwa | - |
dc.contributor.affiliatedAuthor | Kim, Mi Jung | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.3346/jkms.2018.33.e102 | - |
dc.identifier.scopusid | 2-s2.0-85047198889 | - |
dc.identifier.wosid | 000432879900001 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.33, no.21, pp.1 - 9 | - |
dc.relation.isPartOf | Journal of Korean Medical Science | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 33 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 9 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002347164 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | HUMAN PLATELETS | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | CORD BLOOD | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | G-CSF | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Granulocyte-colony Stimulating Factor (G-CSF) | - |
dc.subject.keywordAuthor | Peripheral Blood Mononuclear Cells | - |
dc.subject.keywordAuthor | Cerebral Palsy | - |
dc.identifier.url | https://jkms.org/DOIx.php?id=10.3346/jkms.2018.33.e102 | - |
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