Increased circulating plasma cells detected by flow cytometry predicts poor prognosis in patients with plasma cell myeloma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Mi Hyun | - |
dc.contributor.author | Park, Chan-Jeoung | - |
dc.contributor.author | Kim, Bo Hyun | - |
dc.contributor.author | Cho, Young-Uk | - |
dc.contributor.author | Jang, Seongsoo | - |
dc.contributor.author | Lee, Dong-Hyun | - |
dc.contributor.author | Seo, Eul-Ju | - |
dc.contributor.author | Yoon, Dok Hyun | - |
dc.contributor.author | Lee, Jung-Hee | - |
dc.contributor.author | Suh, Cheolwon | - |
dc.date.accessioned | 2022-07-11T22:11:34Z | - |
dc.date.available | 2022-07-11T22:11:34Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.issn | 1552-4949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/150100 | - |
dc.description.abstract | BackgroundFlow cytometry (FC) is a reliable tool for diagnosing and monitoring of plasma cell myeloma (PCM). Recent studies used FC for quantifying plasma cells (PCs) in peripheral blood (PB) using various panels, and an adverse prognostic effect of circulating PCs (cPCs) has been reported. We investigated the prognostic implication of cPCs quantified using a simple panel in patients with PCM. MethodsBone marrow (BM) and PB of 85 patients with PCM were analyzed by five-color FC at time of diagnosis. A serial gating strategy for quantification used CD38/CD138 to gate PCs in 100,000-200,000 acquired events, with subsequent gating for CD19, CD56, and CD45, to identify aberrant immunophenotypes. ResultscPCs were observed in 74.1% patients (63/85, median 0.067% leukocytes). Patients were grouped based on a cPC cut-off level of 0.02% derived using the receiver operating characteristic curves. Compared with patients with cPCs<0.02% (n=28), those with cPCs0.02% (n=57) showed lower hemoglobin (P=0.003) and platelets (P=0.014), but higher calcium, M-protein and BM PCs (P=0.013, 0.029, and P<0.001, respectively). Survival analysis of 74 patients showed that cPCs0.02% predicted shorter progression-free and overall survival (P=0.001 and 0.013, respectively), and this negative prognostic impact was retained in multivariate analysis (P=0.023). ConclusionsFlow cytometric quantification of cPCs using five surface antigens (CD138, CD38, CD56, CD19, and CD45) is a sensitive and simple method that can be used for assessing PCM prognosis; it would allow clinical laboratories to readily adopt a risk stratification strategy based on cPC levels in PCM patients. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.title | Increased circulating plasma cells detected by flow cytometry predicts poor prognosis in patients with plasma cell myeloma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bae, Mi Hyun | - |
dc.identifier.doi | 10.1002/cyto.b.21606 | - |
dc.identifier.scopusid | 2-s2.0-85039547564 | - |
dc.identifier.wosid | 000434087400015 | - |
dc.identifier.bibliographicCitation | CYTOMETRY PART B-CLINICAL CYTOMETRY, v.94, no.3, pp.493 - 499 | - |
dc.relation.isPartOf | CYTOMETRY PART B-CLINICAL CYTOMETRY | - |
dc.citation.title | CYTOMETRY PART B-CLINICAL CYTOMETRY | - |
dc.citation.volume | 94 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 493 | - |
dc.citation.endPage | 499 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | MINIMAL RESIDUAL DISEASE | - |
dc.subject.keywordPlus | DIAGNOSED MULTIPLE-MYELOMA | - |
dc.subject.keywordPlus | RISK STRATIFICATION | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | circulating plasma cells | - |
dc.subject.keywordAuthor | plasma cell myeloma | - |
dc.subject.keywordAuthor | flow cytometry | - |
dc.subject.keywordAuthor | prognosis | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/cyto.b.21606 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.